{"created":"2023-07-27T07:00:57.096317+00:00","id":61065,"links":{},"metadata":{"_buckets":{"deposit":"1357a618-d429-4891-8275-be4ab17ea7aa"},"_deposit":{"created_by":18,"id":"61065","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"61065"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00061065","sets":["2812:2813:2841"]},"author_link":["22029","20400"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1994-03-23","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"3p.","bibliographicVolumeNumber":"1990 – 1992","bibliographic_titles":[{"bibliographic_title":"平成4(1992)年度 科学研究費補助金 一般研究(B) 研究成果報告書概要"},{"bibliographic_title":"1992 Fiscal Year Final Research Report Summary","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"高体温下のヒトの頭部の皮膚血流量、発汗量、導出静脈と眼静脈の血流量、食道温と鼓膜温、全身の皮膚温等を連続して測定した。(1)、眼角-眼静脈経由で頭蓋内に流入する血流は、深部体温が上昇しある高さになると急に増加し、それ以降は食道温の上昇率は変らずに、鼓膜温のそれだけが低くなった。眼角静脈の機械的圧迫で、鼓膜温の上昇率が増加し、鼻翼のレベルで顔面静脈を圧迫し眼静脈血流を増やすと、その逆の変化が起きた。(2)、眼静脈血流量が急激に増える時点の鼓膜温は、体加温を行なう方法が相違しても、ほぼ一定であった。(3)、厚手の化粧後体温を上げた場合、鼓膜温の上昇率が無化粧の場合より、わずかながら大きかった。(4)、高体温時に被験者の体位を仰向けから直立、あるいは30ﾟ頭上位に変換すると、食道温の上昇率はほとんど変らずに、鼓膜温のそれだけが有意に抑えられた。後者の時には眼静脈、乳突導出静脈の血流量が前者の時より有意に増加した。(5)、導出静脈の血流動態には個人差があり、その理由を考察した。(6)、全身の皮膚温が高い時に、鼓膜温をあるレベル以上に上げても、もはや熱放散量のそれ以上の増加が起こらない(プラトー形成)ことが多い。したがって、プラトーを形成する温度より高い鼓膜温下では、その下降はもはや熱放散反応を抑制するものではない事を確認した。以上の結果から、ヒトが高体温になった時、導出静脈、眼静脈の血流の著しい増加が起きることにより、脳が選択的に冷却される可能性が示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"We measured skin blood flow and sweating rate of the head, blood flow in the angular oculi and mastoid emissary veins, esophageal, tympanic, and mean skin temperatures during whole body hyperthermia in male volunteers. 1. When angular oculi flow was obstructed for 8-10 min while core temperatures were still rising, the rate of rise in tympanic temperature increased than before but that in esophageal temperature did not change. When angular oculi flow was increased by skin compression over the facial veins at an alinasl level, the rate of rise in tympanic temperature decreased than before but esophageal temperature did not change. 2. Tympanic temperature at which a sharp increase of flow occurred in angular oculi veins was the same in either passive body warming or exercise. 3. Temperature difference between the esophagus and the tympanum [Tes-Tty] became less in the subjects with heavy make-up than in those without. 4. When body posture was changed from supine to a 30ﾟ head-up position, blood flows in angular oculi and mastoid emissary veins were increased with a fall in the rate of rise in tympanic temperature. When the subjects remained supine, [Tes-Tty] remained small for the entire period of whole body hyperthermia. 5. During body warming, mean skin temperature reached 37-38ﾟC and skin blood flow and sweating rate of the face reached a plateau even when core temperatures were still rising. We suggest that the fall in brain temperature by selective brain cooling would not suppress the heat loss responses as far as brain temperature is within the range of temperature at which the heat loss responsesare at their maximum level. From these results, we conclude that selective brain cooling is possible and important in humans. Selective brain cooling is achieved by inflow of venous blood, cooled on the scalp and face by evaporation of sweat, through the emissary and ophtahalmic veins into the intracranium.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:02454128, 研究期間(年度):1990 – 1992","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「高体温時のヒトの導出静脈血流動態と選択的脳冷却」課題番号02454128\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-02454128/024541281992kenkyu_seika_hokoku_gaiyo/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医学部","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00067309","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=80023646"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=80023646","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-02454128/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-02454128/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-02454128/024541281992kenkyu_seika_hokoku_gaiyo/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-02454128/024541281992kenkyu_seika_hokoku_gaiyo/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-10-27"}],"displaytype":"detail","filename":"ME-PR-NAGASAKA-T-kaken 1994-3p.pdf","filesize":[{"value":"139.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-NAGASAKA-T-kaken 1994-3p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/61065/files/ME-PR-NAGASAKA-T-kaken 1994-3p.pdf"},"version_id":"99865ad2-b60a-4a85-ab11-6b7aa9e37195"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"高体温時のヒトの導出静脈血流動態と選択的脳冷却","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"高体温時のヒトの導出静脈血流動態と選択的脳冷却"},{"subitem_title":"Emissary venous flow and selective brain cooling in hyperthermic human subjects.","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2841"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-10-27"},"publish_date":"2022-10-27","publish_status":"0","recid":"61065","relation_version_is_last":true,"title":["高体温時のヒトの導出静脈血流動態と選択的脳冷却"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:02:31.266116+00:00"}