{"created":"2023-07-27T07:00:57.250313+00:00","id":61068,"links":{},"metadata":{"_buckets":{"deposit":"00c62eec-8425-4704-b2f3-099dfeb9672f"},"_deposit":{"created_by":18,"id":"61068","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"61068"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00061068","sets":["2812:2813:2842"]},"author_link":["20433","22228"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1993-03-15","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"2p.","bibliographicVolumeNumber":"1990 – 1991","bibliographic_titles":[{"bibliographic_title":"平成3(1991)年度 科学研究費補助金 一般研究(B) 研究成果報告書概要"},{"bibliographic_title":"1991 Fiscal Year Final Research Report Summary","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"平成2、3年の本研究で得られた結果の概要は以下の通りである。\n1.新生児T細胞はCD45RO陰性、CD45RA陽性のnaiveT細胞の形質及び機能的性状をもつが、強いサプレッサ-活性、刺激培養の結果CD45RA陽性からCD45RO陽性に形質転換したmemory様細胞にあっても、ヘルパ-活性はなお不良であるなど、成人naiveT細胞と異なる。\n2.Tγδ細胞の比率は加齢につれ増し、これは主としてCD45RO抗原陽性、抗原応答性をもつBB3陽性サブセットの増加による。が、末梢血の小集団のδTCSー1陽性細胞はCD45RO陰性のnaiveT細胞の性状を示す。\n3.抗CD2抗体によるmemory CD4^+T細胞の増殖反応は単球非存在下でも良好で、ILー2のみならずILー6を産生。他方、naive CD4^+T細胞の抗CD2抗体反応性は微弱であり、ILー6産生欠如が要因である。\n4.伝染性単核症では、CD8^+のみならずCD4^+T細胞がCD45RO抗原を強く発現、CD45RO発現は本症における両T細胞サブセットのEBウイルス感染による活性化状態を示唆する。\n5.抗原応答性というmemoryT細胞の本来の機能に関連して、末梢血memoryT細胞はILー2Rを構成する2つのサブユニット(α、β鎖)を発現。つまり、memory CD4^+T細胞はILー2Rα鎖を、memory CD8^+T細胞はILー2Rβ鎖を発現、ILー2Rサブユニット発現に対応して、memoryT細胞サブセットはILー2添加に強く反応、増殖する。\n6.新生児、小児末梢血CD4^+T細胞の中に、naive形質をもつが、ILー2Rα鎖を発現、memory細胞としてのサイトカイン遺伝子発現能を有する、naiveからmemoryT細胞へ分化途上の小細胞集団が存在する。\n7.全血法により、成熟新生児ではILー6産生能は成人に匹敵するが、未熟児のILー6産生能は未成熟であり、ことに細菌刺激に対するILー6産生が不良であることを明かとした。","subitem_description_type":"Abstract"},{"subitem_description":"Naive and memory T cell populations can be discriminated by differential expression of CD45 isoforms. These studies were undertaken to elucidate some functional characteristics of neonatal inherently naive T cells and their maturation steps into memory T cells following increased antigenic exposure after birth. Obtained results are follow as.\n1) Although neonatal T cells share with adult naive T cells in terms to CD45RA expression, they have strong suppressor activity and less helper activity for B cell differentiation even after memory cells-like phenotypic changes by activation.\n2) BB3^+ subsets within T-gamma/delta^+ T cells, but not deltaTCS-1^+ cells, express CD45RO and have the ability to respond to the antigen.\n3) Naive CD4^+ T cells, unlike memory ones, are hyporesponsive to anti-CD2 stimulation, based on their inability to produce IL-6.\n4) Both CD4^+ and CD8^+ T cell populations express CD45RO as well as HLA-DR antigens, indicating strong stimulation with Epstein-Barr infection.\n5) Memory T cells express IL-2 receptor subunits (alpha or chains) and respond well to exogenous IL-2.\n6) A novel population of CD4^+ T cells with naive (CD45RA^+, CD45RO^-) phenotype expressing IL-2R alpha-chain, which express memory-like functions, are identifiable in the blood of newborns and young children. This population represents the cells at the transitional stage from naive to memory T cells.\n7) Full-term newborns can produce IL-6 in response to bacterial pathogens, but IL-6-producing capabilities of preterm babies are still immature.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:02454268, 研究期間(年度):1990 – 1991","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「新生児NaiveT細胞の機能的特異性とMemoryT細胞への分化・成熟」課題番号02454268\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-02454268/024542681991kenkyu_seika_hokoku_gaiyo/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医学部附属病院","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00067312","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=10143885"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=10143885","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-02454268/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-02454268/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-02454268/024542681991kenkyu_seika_hokoku_gaiyo/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-02454268/024542681991kenkyu_seika_hokoku_gaiyo/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-10-27"}],"displaytype":"detail","filename":"HO-PR-MIYAWAKI-T-kaken 1993-2p.pdf","filesize":[{"value":"93.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-MIYAWAKI-T-kaken 1993-2p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/61068/files/HO-PR-MIYAWAKI-T-kaken 1993-2p.pdf"},"version_id":"1be49a37-2a39-4741-b506-6ba4bcb7700e"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"新生児NaiveT細胞の機能的特異性とMemoryT細胞への分化・成熟","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"新生児NaiveT細胞の機能的特異性とMemoryT細胞への分化・成熟"},{"subitem_title":"Functional Characteristics of Neonatal Naive T cell and Their Maturation into Memory T cell","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2842"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-10-27"},"publish_date":"2022-10-27","publish_status":"0","recid":"61068","relation_version_is_last":true,"title":["新生児NaiveT細胞の機能的特異性とMemoryT細胞への分化・成熟"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:02:27.351284+00:00"}