{"created":"2023-07-27T07:01:03.985341+00:00","id":61211,"links":{},"metadata":{"_buckets":{"deposit":"43308d19-1b92-47a9-8c29-32ff2c88b5ca"},"_deposit":{"created_by":18,"id":"61211","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"61211"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00061211","sets":["2812:2813:2841"]},"author_link":["62766"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1994-03-23","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"2p.","bibliographicVolumeNumber":"1991 – 1992","bibliographic_titles":[{"bibliographic_title":"平成4(1992)年度 科学研究費補助金 一般研究(C) 研究成果報告書概要"},{"bibliographic_title":"1992 Fiscal Year Final Research Report Summary","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"10日間以上,暗期後半の約5時間のみ繰返し暑熱暴露したラットは,24℃の環境で深部体温及び熱産生量(M)がかつての暴露時間帯に限り低下する。これは,暑熱刺激に対する記憶が形成され,刺激がなくても対暑反応が起きたためと推察される(Shido et al.,1991)。本研究はこの現象の機序を追及することを目的とした。ラットを毎日暗期の後半5時間のみ33℃に暴露し,他の時間は24℃で飼育した群(HE)と終日24℃で飼育した群(CN)に分け,2週間以上それぞれの温熱環境に馴化させた。実験1:血中代謝ホルモン及びエネルギー基質の日内変動を検討するため,馴化期間終了直前及び終了第一日目に,0時から18時まで(3時から15時までは暗期)3時間おきにラットを断頭し採血を行った。暑熱暴露中の甲状線ホルモン(T3,T4)はHEで同時間帯のCNに比べ有意に低かったが,馴化期間終了後のかつての暴露時間帯では有意に高かった。T3,T4は代謝を増加させるため,かつての暴露時間帯での体温,Mの低下をT3,T4の低下では説明できない。血中エネルギー基質は暴露後HEとCNで差がなかった。実験2:馴化期間終了後ラットを環境温24℃の直接熱量計に入れ,連続暗期下で視床下部温(Thr),熱放散量(H),M,行動量(BM),摂食活動量(FA)を測定した。HEではかつての暴露時間帯に限りThy,M,H,BM,FAがCNの値に比べ有意に低下した。摂食後は摂食性熱産生のためMが増加する。ところが測定開始6時間前より絶食させ同じ実験を行っても,暴露時間帯のThyがHEで有意に低く,Mも低い傾向があった。従ってこのThy,Mの低下にはFAの変化以外の要因の関与が大きいと結論できた。以上本研究では,繰返し暑熱暴露後,かつての暑露時間に見られるThy,Mの低下には血中代謝ホルモンやエネルギー基質変化,摂食活動の変化以外の関与が大きいことが判明した。今後さらなる検討が必要である。","subitem_description_type":"Abstract"},{"subitem_description":"After the rats were exposed to heat loaded for about 5 h during the last half of the dark phase for 10 consecutive days, body temperature of the rats significantly decreased during the period corresponding to that of the previous heat exposure time (Shido et al., 1991). The objective of this project was to clarify the mechanism of characteristic fall in body temperature. The heat-exposed (HE) rats were subjected to 33.0ﾟC for about 5 h in the last half of the dark phase for more than 2 weeks and control (CN) rats were kept at 24ﾟC. After the completion of the schedule, the levels of hypothalamic temperature (Thy), heat loss, heat production, feeding activity (FA) and body movement were significantly lower in the HE than in the CN during the period when the HE rats had been exposed to heat. Even in fasting condition from 6 h before the start of the experiment, significant difference in Thy still existed. These results suggest that the characteristic fall in Thy is partly mediated by the decrease in FA, however, there are also another contributors. To investigate the contribution of plasma levels of thyroid hormones and energy substrates, plasma levels of triiodothyronine (T3), free T3 (FT3), thyroxin (T4), free T4 (FT4), triglyceride, non esterified fatty acid, total protein and glucose were measured at 3 h interval between 0000 and 1800 h (dark phase, 0300-1500 h). Plasma levels of T3 and FT3 during the previous heat exposure period were significantly higher in the HE than in the CN. Similar differences were observed in T4 and FT4 levels. Plasma levels of energy substrates did not differ between 2 groups. These results suggest minimum contributions of thyroid hormones to the characteristic falls in Thy in the HE rats. Farther studies are required to clarify the mechanisms of the characteristic fall in Thy.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:03670074, 研究期間(年度):1991 – 1992","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「繰返し温熱負荷による体温日内変動の修飾」課題番号03670074\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-03670074/036700741992kenkyu_seika_hokoku_gaiyo/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医学部","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00067455","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=00215691"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=00215691","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-03670074/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-03670074/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-03670074/036700741992kenkyu_seika_hokoku_gaiyo/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-03670074/036700741992kenkyu_seika_hokoku_gaiyo/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-10-24"}],"displaytype":"detail","filename":"ME-PR-SAKURADA-S-kaken 1994-2p.pdf","filesize":[{"value":"95.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-SAKURADA-S-kaken 1994-2p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/61211/files/ME-PR-SAKURADA-S-kaken 1994-2p.pdf"},"version_id":"78e8e9f9-6e41-4b00-867f-80a1b21fe111"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"繰返し温熱負荷による体温日内変動の修飾","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"繰返し温熱負荷による体温日内変動の修飾"},{"subitem_title":"Effect of heat exposure on the diurnal change of body temperature","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2841"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-10-24"},"publish_date":"2022-10-24","publish_status":"0","recid":"61211","relation_version_is_last":true,"title":["繰返し温熱負荷による体温日内変動の修飾"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:05:15.417697+00:00"}