{"created":"2023-07-27T07:01:09.261585+00:00","id":61330,"links":{},"metadata":{"_buckets":{"deposit":"5e639da1-d2db-438e-8daa-2436ba5622ea"},"_deposit":{"created_by":18,"id":"61330","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"61330"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00061330","sets":["2812:2813:2843"]},"author_link":["22029","20400"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1993-08-11","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"2p.","bibliographicVolumeNumber":"1988 – 1990","bibliographic_titles":[{"bibliographic_title":"平成2(1990)年度 科学研究費補助金 総合研究(A) 研究成果報告書概要"},{"bibliographic_title":"1990 Fiscal Year Final Research Report Summary","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"1.巣離視床下部ニュ-ロンによる温度受容機構を解析した。冷信号の収束を受けてふるえをセットする脳幹ニュ-ロン群が確認された。視床下部の温度ニュ-ロンが体温調節行動の動機づけ、報酬認知などの情報処理をもすることが示された。2.内困性発熱物質の作用発現の重要な脳の終板器管の血管内皮細胞に、ILー1などが実際にとり込まれることを確認した。発熱の急性相反応は血中の内困性発熱物質の標的細胞への直接作用によるが、視床下部ニュ-ロンを介して中枢性に調節されことも示された。3.視床下部温度中枢の1側加温により、その側の唾液分泌が増加したが、皮膚加温ではかかる偏側唾液分泌がない。皮膚からの温度情報は、統合された後唾液分泌に伝達されることが示された。情緒刺激に際し、発汗量の一過性増加に先行して鼓膜温が上昇した。星状神経節遮断によりその側の鼓膜温が低下(血流は増加)、偏側の脳障害患者ではその側の代謝が低く鼓膜温が低い。4.ヒトの頭皮・顔面の導出静脈血の頭蓋内への流入が選択的頭冷却機構に特に重要であることが示された。5.非温熱性ストレスと寒冷間に交叉適が成立し、それに褐色脂肪の熱産生の促進が関与する。暑熱時の皮膚血流調節には中心循環系からのフィ-ドバックが存在し、これが脱水時に高感度になる。暑熱時の運動で代謝抑制の存在、下垂体、甲状線ホルモンによる温度馴化時の代謝の変化、高体温、低体温時の血液と細胞内外K^+の変化と体温調節系への修飾などが明らかにされた。暑熱下の運動でおこるATの変化の原困について明らかにされた。6.急性暑熱負荷後各種臓器の細胞内にヒ-トショック蛋白(HSP)が形成されるがナキウサギにはその形成がない。その他HSPと暑熱耐性の関わりが明らかにされた。免疫監視機構の主役であるNK細胞の温度依存性が検討され、NK細胞活性はT細胞と異なり、36ー38ﾟCで最も高いことが示された。","subitem_description_type":"Abstract"},{"subitem_description":"The followings have been clarified by this three-year co-operative research.\n(1) Thermoreceptive mechanisms within the hypothalamus using an isolated tissue.\nModullary neurons receive cold information and control shivering. Control of higher brain activity by thermosensitive neurons in the hypothalamus.\n(2) Importance of the OVLT to induce fever by endogenous pyrogens. Acute phase response is controlled by thermoregulatory neurons in the hypothalamus.\n(3) Unilateral control of thermal saliva secretion by the hypothalamus. No unilateral control of thermal saliva secretion by skin warming. Tympanic temperature rises before thermal sweating by emotional stress. Sweat expulsion would be an indicator of central sweating activity. Unilateral suppression of sweating and fall of tympanic temperature after stellate ganglion blockade.\n(4) Selective brain cooling is evident in humans during hyperthermia. Importance of inward flowing of venous blood from the head and face skin to the intracranium.\n(5) Cross acclimation between cold and non-thermal stress. Importance of BAT for the cross acclimation. Negative feed back mechanisms from the central circulatory system to skin blood flow. Exercise at high temperatures suppress metabolism. pH and K-ion concentration change in blood after hypo- and hyperthermia.\n(6) Heat shock protein and species difference. Temperature dependency of NK-cells.\nClose relation of immune responses to temperature regulation.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:63304033, 研究期間(年度):1988 – 1990","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「体温調節機構の細胞過程から個体反応に至り統合的研究」課題番号63304033\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-63304033/633040331990kenkyu_seika_hokoku_gaiyo/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医学部","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00067573","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=80023646"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=80023646","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-63304033/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-63304033/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-63304033/633040331990kenkyu_seika_hokoku_gaiyo/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-63304033/633040331990kenkyu_seika_hokoku_gaiyo/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-11-07"}],"displaytype":"detail","filename":"ME-PR-NAGASAKA-T-kaken 1993-2p.pdf","filesize":[{"value":"101.1 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-NAGASAKA-T-kaken 1993-2p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/61330/files/ME-PR-NAGASAKA-T-kaken 1993-2p.pdf"},"version_id":"a05dc0d1-23e8-4b1a-969e-5c27a3ad4edb"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"体温調節機構の細胞過程から個体反応に至り統合的研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"体温調節機構の細胞過程から個体反応に至り統合的研究"},{"subitem_title":"Thermoregulatory Mechanisms - from Cellular Process to Organism Response -","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2843"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-11-07"},"publish_date":"2022-11-07","publish_status":"0","recid":"61330","relation_version_is_last":true,"title":["体温調節機構の細胞過程から個体反応に至り統合的研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T11:47:48.613184+00:00"}