{"created":"2023-07-27T07:01:10.122723+00:00","id":61352,"links":{},"metadata":{"_buckets":{"deposit":"8e10772d-9a52-4372-bf6f-049d85c707b0"},"_deposit":{"created_by":18,"id":"61352","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"61352"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00061352","sets":["2812:2813:2843"]},"author_link":["20563","23652"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1993-08-11","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"1988 – 1989","bibliographic_titles":[{"bibliographic_title":"平成1(1989)年度 科学研究費補助金 一般研究(A) 研究成果報告書概要"},{"bibliographic_title":"1989 Fiscal Year Final Research Report Summary","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"フェオフオルバイト(PHー1126),ヘマトポルフィリン・オリゴマ-(HpO,MW:3000),フタロサイアニン・アルミニウム錯体(ALPC)などの新しい光感受性物質につき,KKー47膀胱癌細胞,担癌マウス腫瘍を用い,HPLCによる腫瘍細胞内や,腫瘍組織内取り込み,体内薬物動態,さらに種々の分光学的解析による分子形態の解析,アルゴン色素レ-ザ-(630nm),金蒸気レ-ザ-(628nm),チタン・サファイヤレ-ザ-(675nm)などを用いた光力学的反応(PDT)に基き従来のヘマトポルフィリン誘導体(HpD)と比較検討した。何れの薬剤も細胞,あるいは腫瘍親和性においてHpDより優れ,630nmレ-ザ-光照射のよるPDT効果では,HpDーPDTに場合の比し,同等,或いはそれ以上の抗腫瘍効果が認められた。AIPCに関しては,最大吸収波長が675nmと長波長側にあり,675nmを発振するチタン・サファイアレ-ザ-を用いることにより,光の組織深違性が向上し,HpDに比し優位に高いPDT効果が得られ,アルゴン色素レ-ザ-の1/3の光エネルギ-で同等のPDT効果が得られた。また組織内代謝が早く,皮膚よりの排泄がよく,長波長紫外線による皮膚過敏症がHpDに比し軽微であった。今回の研究では,ALPCが最も有望な新しい光感受性物質と見なされた。蛍光分光学的研究により,HpDは細胞,或いは腫瘍組織内取り込みにより会合体を形成することが,生体類似の溶媒系における蛍光スペクトルとの比較より示された。また,この会合体形成物はマイクロ波によるハイパ-サミア効果を増強することが認められた。抗癌剤アドリアマイシン(ADM)投与後のHpDーPDTには光力学的抗腫瘍効果の増強が期待でき,in vitroにおける光力学的殺細胞効果にはADMの抗癌化学効果との間に相乗的効果の増大が認められた。","subitem_description_type":"Abstract"},{"subitem_description":"To identify a more promising photosensitizer than HpD, which has been widely used in clinical PDT, we have done a comparative study on three new photosensitizers : Pheophorbide derivative (PH-1126), Hematoporphyrin oligomer (HpO, M. W. : 3,000) or Aluminium phthalocyanine (AlPC), in regard to cellular and tumoral uptake of photosensitizers, pharmacokinetic study, spectroscopic study and photodynamic tumor eradicating ability with laser light irradiation. Argon dye laser (ADL, 630 nm), Gold vapor laser (GVL, 628 nm) and Titanium-sapphire laser (TSL, 675 nm) were applied to the present study.\nAll of three photosensitizers showed better cellular or tumoral uptake compared to HpD. After sensitization with each of the new photosensitizers, irradiation with ADL or GVL showed comparable tumor destruction to HpD-PDT on a tumor bearing nude mice system.\nAlPC, having an advantage of good absorption in red light region with a peak at 675 nm, revealed stronger tumor regression using TSL than HpD on the nude mice tumor system. This laser, emitting a light of 675 nm in wavelength, has deep tissue penetration compared to ADL or GVL.\nTissue distribution study revealed that more AlPC localized in malignant tumor than HpD and skin concentration of AlPC was more rapidly reducing after drug administration than that of HpD. HpD-injected group showed stronger skin hypersensitivity after long wave ultraviolet exposure on mice dorsal skin.\nThese results suggested that ALPC may be the most promising photosensitizer in PDT.\nComparative studies on the fluorescence spectroscopic properties of several photosensitizers dissolved in aqueous solution and 0.1 mM CTAB micellar solution, biochemically close to human body fluid, suggested that HpO incorporated into tumor cells and tissues was thought to be aggregated.\nFurther, it was shown that the cell killing effects of microwave hyperthermia was enhanced by the presence of aggregatedーHpO.\nAn in vitro experimental study of a combination therapy of adriamycin and HpD-PDT on KK-47 bladder cancer cells showed that adriamycin treatment followed by HpD-PDT resulted in joint potentiation in cell killing effect.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:63440060, 研究期間(年度):1988 – 1990","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「光力学的癌治療における新しいより有効な光感受性物質の利用と開発に関する研究」課題番号63440060\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-63440060/634400601990kenkyu_seika_hokoku_gaiyo/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医学部","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00067595","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=70019537"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=70019537","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-63440060/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-63440060/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-63440060/634400601990kenkyu_seika_hokoku_gaiyo/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-63440060/634400601990kenkyu_seika_hokoku_gaiyo/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-11-07"}],"displaytype":"detail","filename":"ME-PR-HISAZUMI-H-kaken 1993-5p.pdf","filesize":[{"value":"237.1 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-HISAZUMI-H-kaken 1993-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/61352/files/ME-PR-HISAZUMI-H-kaken 1993-5p.pdf"},"version_id":"9a332034-579a-46a5-b57a-22ed05b4e32f"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"光力学的癌治療における新しいより有効な光感受性物質の利用と開発に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"光力学的癌治療における新しいより有効な光感受性物質の利用と開発に関する研究"},{"subitem_title":"The Development of New Potent Photosensitizers in Photodynamic Cancer Therapy","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2843"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-11-07"},"publish_date":"2022-11-07","publish_status":"0","recid":"61352","relation_version_is_last":true,"title":["光力学的癌治療における新しいより有効な光感受性物質の利用と開発に関する研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T11:47:08.212923+00:00"}