{"created":"2023-07-27T07:01:10.762763+00:00","id":61372,"links":{},"metadata":{"_buckets":{"deposit":"e5d9dfbc-8185-4a35-876a-1e3cd938718c"},"_deposit":{"created_by":18,"id":"61372","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"61372"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00061372","sets":["2812:2813:2844"]},"author_link":["22029","20400"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1993-03-25","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"2p.","bibliographicVolumeNumber":"1988 – 1989","bibliographic_titles":[{"bibliographic_title":"平成1(1989)年度 科学研究費補助金 一般研究(A) 研究成果報告書概要"},{"bibliographic_title":"1989 Fiscal Year Final Research Report Summary","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"強い温熱負荷時に起きる末梢循環反応を解析し、暑熱・高体温下での体温調節機構について新たな知見を加えることができた。すなわち、1.温熱皮膚血管収縮反応。ヒトが高体温の時に限り、体温より高い局所温度に皮膚をさらすと、手指、手掌、足蹠等で皮膚血管の収縮とその部の容積の減少が起きた。これは動静脈吻合(AVA)のない前腕皮膚では起きず、また血流の分画測定で手指等の無毛部の血管のうち比較的深部のAVAの反応であることを確認した。この反応は局所の温熱感覚が急増するいわゆるダイナミック相に同期して起きやすく、皮膚交感神経活動の増加とも比例した。皮膚交感神経のブロック後ではこの時交感神経活動の亢進もこの血管収縮も起きず、この反応が交感神経の調節をうけた反応であることが確認されたが、局所の血管平滑筋の直接反応も一部関与する可能性もある。この反応は、既に高体温のヒトで外界から体内への熱移動を遮断する合目的的な反応であると結論した。2.導出静脈の血流と選択的脳冷却。高体温時に顔面への送気は鼓膜温(Tty)の上昇を抑制し、暑熱環境での滞在時間を延長した。その機転を解明する目的で、全身加温時の前額皮膚の血流量、眼角静脈の血流とその方向性を測定した。前額皮膚温、Tty、食道温(Tes)、平均皮膚温をサ-ミスタ-で、発汗量の変化をカプセル法で同時に測定した。高体温時にTes、Ttyが一定の率で上昇している最中に、眼角静脈経由で顔面皮膚から頭蓋底へ流入する血流を機械的に阻害すると、Ttyの上昇率のみが更に増加した。Tes、Ttyの上昇率が一定の時に顔静脈を機械的に圧迫すると、眼角静脈経由で頭蓋内に入る静脈血流の速度が著しく増加し、Ttyの上昇率のみが減少した。正常のヒトでは暑熱負荷時に、発汗等で冷却された導出静脈血流の増加に原因する選択的脳冷却機構が存在することが推測できた。","subitem_description_type":"Abstract"},{"subitem_description":"We studied thermoregulatory defense responses to extreme heat stress in human subjects. 1. Heat-induced skin vasoconstriction (HIVC). Finger vessels constricted and finger volume decreased when the hand was heated locally to temperature above body core temperature. This vasoconstriction was consistent when the subject was hyperthermic, and was not observed in the forearm skin where arteriovenous anastomoses (AVA) do not exist. HIVC was marked when the subject reported a sharp rise of local thermal sensation. During this period, skin sympathetic nerve activity to the hand increased. Partitional measurements of blood flow through superficial capillaries and deeply located AVA's confirmed that the vascular compartments responsible for HIVC were mainly AVA'S. From these results, we propose that HIVC is a response to retard heat transfer from hot contact objects to the body in already hyperthermic subjects. 2. Selective brain cooling enhanced by inward venous flowing through emissary veins. We confirmed that selective brain cooling via emissary veins such as angular oculi veins (AOV) was an important process enabling brain temperature (indicated by tympanic membrane temperature (T_<ty>)), to become lower than body core temperature in hyperthermic subjects. Mechanical obstruction of flow through AOV resulted an increase in the rise of T_<ty> during whole body warming. Mechanical obstruction of facial veins increased inward flowing of AOV-flow and suppressed the rate of rise in T_<ty>. These results strongly support the idea that emissary veins supply venous blood into the cavernous sinuses which act as a heat sink to cool the brain during hyperthermia in humans.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:61440027, 研究期間(年度):1986 – 1989","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「強度の温熱刺激に対する生体自律防御反射と適応」課題番号61440027\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-61440027/614400271989kenkyu_seika_hokoku_gaiyo/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医学部","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00067615","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/search/?kw=80023646"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/search/?kw=80023646","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-61440027/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-61440027/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-61440027/614400271989kenkyu_seika_hokoku_gaiyo/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-61440027/614400271989kenkyu_seika_hokoku_gaiyo/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-11-04"}],"displaytype":"detail","filename":"ME-PR-NAGASAKA-T-kaken 1993-2p.pdf","filesize":[{"value":"104.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-NAGASAKA-T-kaken 1993-2p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/61372/files/ME-PR-NAGASAKA-T-kaken 1993-2p.pdf"},"version_id":"6b9568e9-026f-4394-9675-0544d1441dd6"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"強度の温熱刺激に対する生体自律防御反射と適応","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"強度の温熱刺激に対する生体自律防御反射と適応"},{"subitem_title":"Autonomic defense responses to extremely strong heat stress","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2844"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-11-04"},"publish_date":"2022-11-04","publish_status":"0","recid":"61372","relation_version_is_last":true,"title":["強度の温熱刺激に対する生体自律防御反射と適応"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T11:49:23.850584+00:00"}