{"created":"2023-07-27T07:01:23.291496+00:00","id":61669,"links":{},"metadata":{"_buckets":{"deposit":"855ca459-f7a6-4510-bf6c-69a99ba04eb4"},"_deposit":{"created_by":18,"id":"61669","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"61669"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00061669","sets":["2812:2813:2846"]},"author_link":["26426","105356"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1989-03-29","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"2p.","bibliographicVolumeNumber":"1986 – 1987","bibliographic_titles":[{"bibliographic_title":"昭和62(1987)年度 科学研究費補助金 一般研究(C) 研究成果報告書概要"},{"bibliographic_title":"1987 Fiscal Year Final Research Report Summary","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"1. (E)-1-ベンジルー7-ホルミルワイをオスミウ酸素化した後, シユウ酸ジクロリドを用いる新しい反応によって環状炭酸ジエステルに導き, 接触還元によって題記超修飾塩基のモデル化合物を得た.\n2. このモデル反応に従って題記塩基に対する標的化合物を合成するために必要な合成するために必要な合成中間体(S)-(E)-1-ベルジルー7-(3-カルボメトキシー3-カルボメイトキシアミノー2-ブテニル)ワイの合成法を改良した. すなわち, 1-ベンジルワイをNaHCO_3存在下I_2との反応によって容易かつ高収率で1-ベンジルー7-ヨードワイとし, ビニルグリシン語導体とのHeck反応によって目的を達した. この反応の操作は非常に簡単なので, ここに重要中間体の大量合成が可能になったものと思われた. しかしながら, 一方の原料である光学的に純粋なビニルグリシンは文献によれば大量に得ることが容易な筈であったが, 現実にはラセミ化を伴い, 収率もよくなかったので, 現在独自の方法による≦-ビニルグリシンの合成法を検討中である.\n3. この合成中間体をオスミウム酸酸化したところ, ジアステレオマーの混合物としてジオール体を得た. これらはシリカゲルカラムによって分離することができ, X線結晶解析によって主成績体の絶対配置を(S,S,S)と決定した. 酸化文応の性質上他方は(R,R,S)一体である. これらを上述のモデル文応にならって選択的に脱オキシ化することによって, 題記超修飾塩基に対する標的化合物7-(3-カルボメトキシー3-カルボメトキシアミノー2-ヒドロキシブチル)ワイの(B,S)-及び(S,S)-体を合成することに成功した.\n4. ここに得た標的化合物の化学的性質の検討及び題記塩基の生体資料からの単離は現在続行中である.","subitem_description_type":"Abstract"},{"subitem_description":"1. The synthesis of a model compound for the title fluorescent base has been established by a series of the reactions: the Witting reaction between 1-benzy1-7-(triphenylphosphoniomethyl)wye and isobutyraldehyde, oxidation with OsO_4, cyclic carbonate formation by treatment with (COCL)_2, and catalytic hydrogenolysis over Pd-C.\n2. The Heck reaction of 1-benzy1-7-iodowye with (S)-N-(methoxycarbonyl)vinylglycine followed by methylation has provided an improved method for the synthesis of'(S)-(E)-1-benzy1-7-[3-methoxycarbonyl-3-(methoxycarbonyl)amino-1-butenyl]wye, the key intermediate for the synthesis of the target compounds. Oxidation of the intermediate with OsO_4 gave a pair of the diastereomers of the diols and the (S,S,S) configurations were assigned to the major product by means of X-ray analysis. According to the model experiments mentioned above, the diols were transformed into [R-(R^*,S^*)]- and [S-(R^*,R^*)]-hydroxywybutine, two alternatives for the title base.\n3. Investigation of the chemical properties of the isomers of hydroxywybutine and isolation of the base from natural sources are in progress.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:61570998, 研究期間(年度):1986 – 1987","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「哺乳動物フェニルアラニン転移リボ核酸の超修飾塩基に関する化学的研究」課題番号61570998\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-61570998/615709981987kenkyu_seika_hokoku_gaiyo/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学薬学部","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00067912","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=20019657"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=20019657","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-61570998/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-61570998/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-61570998/615709981987kenkyu_seika_hokoku_gaiyo/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-61570998/615709981987kenkyu_seika_hokoku_gaiyo/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-11-14"}],"displaytype":"detail","filename":"PH-PR-ITAYA-T-kaken 1989-2p.pdf","filesize":[{"value":"86.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-ITAYA-T-kaken 1989-2p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/61669/files/PH-PR-ITAYA-T-kaken 1989-2p.pdf"},"version_id":"943950e8-4b34-4be3-aabd-f347c510c458"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"哺乳動物フェニルアラニン転移リボ核酸の超修飾塩基に関する化学的研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"哺乳動物フェニルアラニン転移リボ核酸の超修飾塩基に関する化学的研究"},{"subitem_title":"Chemistry of the Hypermodified Base from Mammalian Phenylalanine Transfer Ribonucleic Acids","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2846"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-11-14"},"publish_date":"2022-11-14","publish_status":"0","recid":"61669","relation_version_is_last":true,"title":["哺乳動物フェニルアラニン転移リボ核酸の超修飾塩基に関する化学的研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T11:40:13.445714+00:00"}