{"created":"2023-07-27T07:01:28.299913+00:00","id":61793,"links":{},"metadata":{"_buckets":{"deposit":"d87ce496-b9f6-421e-9826-a464588cab04"},"_deposit":{"created_by":18,"id":"61793","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"61793"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00061793","sets":["2812:2813:2846"]},"author_link":["20563","23652"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1989-03-29","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"2p.","bibliographicVolumeNumber":"1985 – 1987","bibliographic_titles":[{"bibliographic_title":"昭和62(1987)年度 科学研究費補助金 一般研究(A) 研究成果報告書概要"},{"bibliographic_title":"1987 Fiscal Year Final Research Report Summary","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"1.金蒸気レーザ(GVL)は, 分光学的に組織内色素にphotobleachirgを起こし, 大きな組織深達性が得られた. その結果組織内に温熱効果を誘導でき, PDT+温熱の順で用いれば, 光力学的治療(PDT)による細胞膜や蛋白合成障害を有意に増強し, 照射時間を短縮し得た.\n2.AICI-phthalocyanine.HpD-polymer(分子量12,000)はHpDに比し有意に高い光殺細胞効果を示した. HPLC分析でAICI-phthalocyanineに高い腫瘍集積が認められ, 676nmの励起光によりさらに大きいPDT効果が期待された.\n3.ヒト膀胱癌T24細胞から得た3種のモノクローナル抗体とHpD接合体を作ったが, 細胞内取り込みに優位性は認められなかった.\n4.Adriamycin(ADM)とHpDの相互作用についてはADM+HpD(I), ADM→HpD(II), HpD→ADM(III)の処理順にHpDの細胞内取り込みが低下し, ADMの殺細胞効果はII, III, では著変は認められず, Iでは殺細胞効果の低下が認められた.\n5.PDTでは形態学的にミトコンドリア, 細胞膜障害が初発変化で, 核の変化は遅れて認められた.\n6.GVLとHpDを用いたfocal PDTは100J/cm^2以下において2cm以下の15膀胱腫瘍全てにCR.2〜3cmの2腫瘍にPRが得られ, アルゴン色素レーザーを用いたCR58%に比し有意に優れていた.\n7.GVL用高効率導光システムとしてunstable resonator opt-icsと50【bounded integral】, 両凸FL86mmレンズを用い, 600μmファイバーに約75%の高い導光率を得た. 安定発振にはプラズマチューブ内圧を8mBar以下に保つべきであった.\n8.3%イントラリポスを用いた簡単な膀胱壁全照射機を試作し, これを用いて家兎移植膀胱腫瘍, 広汎な膀胱癌15症例にintegral PDTを行い, 20J/cm^2が至適光量で本機の有用性が認められた.\n9.UV光とホトカウンティング撮像装置を用いた内視鏡的HpD螢光画像化システムを考察し, 実験腫瘍においてフィルターR60とDIFを併用し高解像力を得た. 今後臨床的に有望と考えられた.","subitem_description_type":"Abstract"},{"subitem_description":"1. A gold vapor laser (GVL) exerted spectroscopically photobleaching to HpD and other absorbers in tissue which resulted in an increase in tissue penetration and contributed intratumoral 43゜c hyperthermia. A combination of HpD-PDT and the hyperthermia significantly enhanced tumor destruction and cut down irradation time. 2. ALCL-phthalocyanine (PC) and HpD polymer (MW:12000) showed a greater photodynamic cell killing as compared with HpD using 630nm red light. A HPLC study revealed a higher tumor accumulation of PC in tumor-bearing animals. PC was thought to be promising drug in the future. 3. There was no difference of in vitro cellular uptake between HpD and 3 HpD-conjugated monoclonal antibodies obtained from T24 cells. 4. In vitro HpD-cellular uptake was low in the order: HpD-adriamycin(ADM)(a), ADM-HpD(b) and ADM+HpD(c). The cell killing of ADM received no change in (b) and (c), but a decrease in (a). The effect of laser irradiation on these combinations should be studied. 5. The focusing of GVL beam into a 600um optic fiber was significantly increased when an unstable resonator oprics and 50 < ph>mm bilateral convex lens, FL86mm, were used, the transmission rate being approx.75%. 6. Morphological studies of HpD-photodynamic cell killing revealed a marked degradation of mitochondria and cell membrane as an initial change and then followed by nuclear damage. These changes were supported by the data in biochemical studies and in accordance with intracellular HpD distribution. 7. Focal HpD-PDT with less than 100J/sqcm acheved 100 and 58% CR for 15 and 33 bladder tumors less than 2cm in size using the GVL and an argon dye laser, respectively. 8. A simple laser light scattering device using 3% Intralipos was designed for whole bladder wall HpD-PDT and applied to rabbit bladders bearing Vx2 carcinomas and multiple superficial bladder tumors. The device proved to be clinically useful and approx. 20J/sqcm may be suitable. 9. Endoscopic HpD fluorescence cancer imaging system consists of UV light, photoncounting device and R60 and DIF filters was devised and tested for the rabbit bladder tumors. The results were encouraging for clinical application.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:60440075, 研究期間(年度):1985 – 1987","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「癌光化学治療における新しいレーザの応用と, その治療法確立に関する基礎的, 臨床的研究」課題番号60440075\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-60440075/604400751987kenkyu_seika_hokoku_gaiyo/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医学部","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00068036","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=70019537"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=70019537","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-60440075/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-60440075/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-60440075/604400751987kenkyu_seika_hokoku_gaiyo/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-60440075/604400751987kenkyu_seika_hokoku_gaiyo/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-11-10"}],"displaytype":"detail","filename":"ME-PR-HISAZUMI-H-kaken 1989-2p.pdf","filesize":[{"value":"114.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-HISAZUMI-H-kaken 1989-2p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/61793/files/ME-PR-HISAZUMI-H-kaken 1989-2p.pdf"},"version_id":"f2a8ba4a-2a88-43fc-8d56-c4b082bc7261"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"癌光化学治療における新しいレーザの応用と, その治療法確立に関する基礎的, 臨床的研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"癌光化学治療における新しいレーザの応用と, その治療法確立に関する基礎的, 臨床的研究"},{"subitem_title":"The application and evaluation of a newly developed laser to photodynamic cancer therapy","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2846"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-11-10"},"publish_date":"2022-11-10","publish_status":"0","recid":"61793","relation_version_is_last":true,"title":["癌光化学治療における新しいレーザの応用と, その治療法確立に関する基礎的, 臨床的研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T11:44:05.165052+00:00"}