| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-10-03 |
| タイトル |
|
|
タイトル |
MGMT promoter methylation and temozolomide response in choroid plexus carcinoma |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| ID登録 |
|
|
ID登録 |
10.24517/00008451 |
|
ID登録タイプ |
JaLC |
| 著者 |
Misaki, Kouichi
Nakada, Mitsutoshi
Mohri, Masanao
Hayashi, Yutaka
Hamada, Jun-ichiro
|
| 著者別表示 |
見崎, 孝一
中田, 光俊
毛利, 正直
林, 裕
濱田, 潤一郎
|
| 書誌情報 |
Brain Tumor Pathology
巻 28,
号 3,
p. 259-263,
発行日 2011-07-01
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1433-7398 |
| NCID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11203151 |
| DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1007/s10014-011-0033-5 |
| 出版者 |
|
|
出版者 |
Springer Verlag (Germany) |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Choroid plexus carcinoma (CPC) is a malignant tumor with a strong tendency to spread along the cerebrospinal fluid pathway. There is no standardized chemotherapy protocol for this rare tumor. We report a 38-year-old man with CPC in the lateral ventricle with obstructive hydrocephalus. Because of the poor demarcation between thalamus and fornix, subtotal tumor resection was performed. Postoperative spine magnetic resonance (MR) image revealed whole spinal axis dissemination. After diagnosis of CPC, the patient was treated with whole ventricular and spine radiation concomitant with temozolomide chemotherapy, although the O 6-methylguanine-DNA methyltransferase (MGMT) promoter was found to be unmethylated. Although MR images revealed transient stable disease during adjuvant therapy, tumor progression was depicted after four cycles of temozolomide therapy. We discuss the ineffectiveness of adjuvant temozolomide therapy for CPC in connection with O 6-methylguanine-DNA methyltransferase promoter methylation. © 2011 The Japan Society of Brain Tumor Pathology. |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 関連URI |
|
|
|
識別子タイプ |
URI |
|
|
関連識別子 |
http://www.springerlink.com/content/l48v7nk1752m8644/ |
HO-PR-MISAKI-K-259.pdf (356.7 kB)
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