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光電容積脈波式血中アルコール濃度計測装置の開発: in vivo試験による予備的検討
http://hdl.handle.net/2297/32473
http://hdl.handle.net/2297/32473cd1f2051-428c-4227-a05a-6f8db535ad12
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
TE-PR-YAMAKOSHI-T-237.pdf (3.0 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-10-03 | |||||
| タイトル | ||||||
| タイトル | 光電容積脈波式血中アルコール濃度計測装置の開発: in vivo試験による予備的検討 | |||||
| タイトル | ||||||
| タイトル | A preliminary study on development of a novel optical instrument for non-invasive blood alcohol measurement: Proposal of pulse alcometry | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
山越, 健弘
× 山越, 健弘× 小川, 充洋× 松村, 健太× 板坂, 優希× 宮崎, 慎平× 山越, 康弘× Rolfe, Peter× 廣瀬, 元× 山越, 憲一 |
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| 書誌情報 |
Transactions of Japanese Society for Medical and Biological Engineering 巻 50, 号 2, p. 237-247, 発行日 2012-01-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1347-443X | |||||
| NCID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA11633569 | |||||
| 出版者 | ||||||
| 出版者 | Japanese Society for Medical and Biological Engineering = 日本生体医工学会 JSMBE | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In this preliminary study, we examined in human volunteers the performance of the developed prototype device for non-invasive quantification of blood alcohol concentration (BAC) by near-infrared light which is highly transparent to the body. We aimed at applying the results to the final goal of developing a novel alcohol-based vehicle ignition-interlock device. Accumulating evidence shows that one of the ethyl alcohol absorption peaks in the near-infrared region is present at 1,185 nm. We combined this with our recent development of a non-invasive optical method for blood glucose measurement, which we call pulse glucometry, using blood volume pulsations in a finger within a cardiac cycle. Thus, we developed a novel method, pulse alcometry, for non-invasive measurement of BAC. We calculated second derivative values of optical density (OD λ") to remove baseline over a band including three wavelengths, 1,150 nm, 1,185 nm, and 1,220 nm. Then, a simple linear regression analysis was performed with the measured OD λ" to predict BAC levels. In 3 healthy male volunteers, during alcohol intake and washout, periodic optical measurements using the present device were made simultaneously with collection of blood samples for in vitro BAC analysis. In leave-one-out cross validations within an individual, the measured BAC and the predicted BAC correlated well (r = 0.773~0.846, mean absolute error = 0.134~0.333mg/ml). We conclude that, from the results of this preliminary study, the new method appears to be able to estimate BAC levels non-invasively. However, further investigations in a larger group of subjects will be needed in order to determine fully the operational performance of this new measurement system. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 関連URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://ci.nii.ac.jp/naid/40019356725 | |||||
| 関連URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.asas.or.jp/jsmbe/ | |||||
