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Fluorescence intensity and bright spot analyses using a confocal microscope for photodynamic diagnosis of brain tumors
https://doi.org/10.24517/00009256
https://doi.org/10.24517/00009256aee2a194-5518-4a32-b0d0-464c8b2ab57d
| 名前 / ファイル | ライセンス | アクション |
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TE-PR-YONEYAMA-T-13.pdf (1.4 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||
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| 公開日 | 2017-12-05 | |||||||||||||||
| タイトル | ||||||||||||||||
| タイトル | Fluorescence intensity and bright spot analyses using a confocal microscope for photodynamic diagnosis of brain tumors | |||||||||||||||
| 言語 | ||||||||||||||||
| 言語 | eng | |||||||||||||||
| 資源タイプ | ||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||
| 資源タイプ | journal article | |||||||||||||||
| ID登録 | ||||||||||||||||
| ID登録 | 10.24517/00009256 | |||||||||||||||
| ID登録タイプ | JaLC | |||||||||||||||
| 著者 |
Yoneyama, Takeshi
× Yoneyama, Takeshi× Watanabe, Tetsuyo× Kagawa, Hiroyuki× Hayashi, Yutaka× Nakada, Mitsutoshi |
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| 著者別表示 |
米山, 猛
× 米山, 猛
× 渡辺, 哲陽
× 香川, 博之
× 林, 裕
× 中田, 光俊
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| 書誌情報 |
Photodiagnosis and Photodynamic Therapy 巻 17, p. 13-21, 発行日 2017-03-01 |
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| ISSN | ||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||
| 収録物識別子 | 1572-1000 | |||||||||||||||
| NCID | ||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||
| 収録物識別子 | AA11969923 | |||||||||||||||
| DOI | ||||||||||||||||
| 関連タイプ | isVersionOf | |||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||
| 関連識別子 | 10.1016/j.pdpdt.2016.11.002 | |||||||||||||||
| 出版者 | ||||||||||||||||
| 出版者 | Elsevier B.V. | |||||||||||||||
| 抄録 | ||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||
| 内容記述 | Background In photodynamic diagnosis using 5-aminolevulinic acid (5-ALA), discrimination between the tumor and normal tissue is very important for a precise resection. However, it is difficult to distinguish between infiltrating tumor and normal regions in the boundary area. In this study, fluorescent intensity and bright spot analyses using a confocal microscope is proposed for the precise discrimination between infiltrating tumor and normal regions. Methods From the 5-ALA-resected brain tumor tissue, the red fluorescent and marginal regions were sliced for observation under a confocal microscope. Hematoxylin and eosin (H&E) staining were performed on serial slices of the same tissue. According to the pathological inspection of the H&E slides, the tumor and infiltrating and normal regions on confocal microscopy images were investigated. From the fluorescent intensity of the image pixels, a histogram of pixel number with the same fluorescent intensity was obtained. The fluorescent bright spot sizes and total number were compared between the marginal and normal regions. Results The fluorescence intensity distribution and average intensity in the tumor were different from those in the normal region. The probability of a difference from the dark enhanced the difference between the tumor and the normal region. The bright spot size and number in the infiltrating tumor were different from those in the normal region. Conclusions Fluorescence intensity analysis is useful to distinguish a tumor region, and a bright spot analysis is useful to distinguish between infiltrating tumor and normal regions. These methods will be important for the precise resection or photodynamic therapy of brain tumors. © 2016 Elsevier B.V. | |||||||||||||||
| 内容記述 | ||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||
| 内容記述 | Embargo Period 12 months | |||||||||||||||
| 権利 | ||||||||||||||||
| 権利情報 | Copyright © Elsevier B.V. (CC-BY NC ND) | |||||||||||||||
| 著者版フラグ | ||||||||||||||||
| 出版タイプ | AM | |||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||
| 関連URI | ||||||||||||||||
| 識別子タイプ | URI | |||||||||||||||
| 関連識別子 | http://www.elsevier.com/locate/issn/15721000 | |||||||||||||||
