WEKO3
インデックスリンク
アイテム
{"_buckets": {"deposit": "3b7e0700-df9a-4896-bc0d-5e8e3cd2252f"}, "_deposit": {"created_by": 3, "id": "27011", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "27011"}, "status": "published"}, "_oai": {"id": "oai:kanazawa-u.repo.nii.ac.jp:00027011", "sets": ["1763"]}, "author_link": ["21707", "595", "652", "21711", "45794", "422", "21709", "45795", "116", "45798", "45796", "45797", "21362"], "item_4_biblio_info_8": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2009-10-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "5", "bibliographicPageEnd": "321", "bibliographicPageStart": "316", "bibliographicVolumeNumber": "15", "bibliographic_titles": [{"bibliographic_title": "Journal of Infection and Chemotherapy"}]}]}, "item_4_description_21": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "We report a 48-year-old man with hepatocellular carcinoma (HCC) treated with hepatic arterial infusion (HAI) chemotherapy followed by proton beam therapy. The HCC lesion in this patient was 88 mm in diameter, with portal vein tumor thrombosis in the right lobe of the liver. He was first treated with 5-fluorouracil, cisplatin, and isovorin, administered by HAI, combined with interferon-α, and he was subsequently treated with epirubicin and mitomycin-C administered by HAI. However, no definite efficacy of either of these treatments was observed. Then, after 3 weeks\u0027 continuous administration of irinotecan by HAI, the tumor size decreased to 68 mm in diameter. However, 3 months after reduction of the tumor, the tumor had become enlarged to 100 mm in diameter and intrahepatic metastases were prominent. Angiographic findings indicated that the HCC was fed not only from the right hepatic artery but also from the left gastric and right and left subphrenic arteries. After rearrangement of the arteries, and 3 months\u0027 continuous HAI chemotherapy with irinotecan, plus hyperthermia, the tumor size had decreased to 50 mm in diameter. The reduction rate of the main tumor according to the Response Evaluation Criteria in Solid Tumors was 43%; therefore, the efficacy of this treatment was judged as a partial response. Two months after reduction of the tumor, the patient\u0027s serum alpha-fetoprotein (AFP) level was elevated, and so docetaxel was administered by HAI instead of irinotecan. The liver tumors showed gradual enlargement during the administration of docetaxel, although the AFP level was suppressed. Proton beam therapy was instituted and the liver tumors showed necrosis after this therapy. The patient died of hepatic failure and distant metastases 6 years after the onset of HCC. As far as we know, this is the first case report of HCC treated effectively with irinotecan administered by HAI followed by proton beam therapy in which tumor suppression and the long-term survival of the patient were observed. © 2009 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases.", "subitem_description_type": "Abstract"}]}, "item_4_description_5": {"attribute_name": "提供者所属", "attribute_value_mlt": [{"subitem_description": "金沢大学医学部附属病院がん高度先進治療センター", "subitem_description_type": "Other"}]}, "item_4_publisher_17": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Springer Verlag (Germany) / 日本化学療法学会"}]}, "item_4_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1007/s10156-009-0702-z", "subitem_relation_type_select": "DOI"}}]}, "item_4_source_id_11": {"attribute_name": "NCID", "attribute_value_mlt": [{"subitem_source_identifier": "AA11057978", "subitem_source_identifier_type": "NCID"}]}, "item_4_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1341-321X", "subitem_source_identifier_type": "ISSN"}]}, "item_4_version_type_25": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Ohtsubo, Koushiro"}], "nameIdentifiers": [{"nameIdentifier": "595", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "60361987", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=60361987"}, {"nameIdentifier": "60361987", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=60361987"}, {"nameIdentifier": "60361987", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000060361987"}]}, {"creatorNames": [{"creatorName": "Watanabe, Hiroyuki"}], "nameIdentifiers": [{"nameIdentifier": "21709", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "30242564", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=30242564"}, {"nameIdentifier": "30242564", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000030242564"}]}, {"creatorNames": [{"creatorName": "Tsuchiyama, Tomoya"}], "nameIdentifiers": [{"nameIdentifier": "45794", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mouri, Hisatsugu"}], "nameIdentifiers": [{"nameIdentifier": "652", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "50397212", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=50397212"}, {"nameIdentifier": "50397212", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000050397212"}]}, {"creatorNames": [{"creatorName": "Yamaguchi, Yasushi"}], "nameIdentifiers": [{"nameIdentifier": "21707", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "20303315", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=20303315"}, {"nameIdentifier": "20303315", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000020303315"}]}, {"creatorNames": [{"creatorName": "Motoo, Yoshiharu"}], "nameIdentifiers": [{"nameIdentifier": "21362", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "80210095", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=80210095"}, {"nameIdentifier": "80210095", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000080210095"}]}, {"creatorNames": [{"creatorName": "Okai, Takashi"}], "nameIdentifiers": [{"nameIdentifier": "45795", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sanada, Junichiro"}], "nameIdentifiers": [{"nameIdentifier": "422", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "10313652", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=10313652"}, {"nameIdentifier": "10313652", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000010313652"}]}, {"creatorNames": [{"creatorName": "Matsui, Osamu"}], "nameIdentifiers": [{"nameIdentifier": "116", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "10019961", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=10019961"}, {"nameIdentifier": "10019961", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000010019961"}]}, {"creatorNames": [{"creatorName": "Kitamura, Tokuji"}], "nameIdentifiers": [{"nameIdentifier": "45796", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fujiki, Ryusuke"}], "nameIdentifiers": [{"nameIdentifier": "45797", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tokuuye, Koichi"}], "nameIdentifiers": [{"nameIdentifier": "45798", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sawabu, Norio"}], "nameIdentifiers": [{"nameIdentifier": "21711", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "90019969", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=90019969"}, {"nameIdentifier": "90019969", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000090019969"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-10-05"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "HO-PR-OHTSUBO-K-316.pdf", "filesize": [{"value": "130.1 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 130100.0, "url": {"label": "HO-PR-OHTSUBO-K-316.pdf", "url": "https://kanazawa-u.repo.nii.ac.jp/record/27011/files/HO-PR-OHTSUBO-K-316.pdf"}, "version_id": "f8b5488f-6379-4390-be01-0e0abbc5f206"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Docetaxel", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Hepatic arterial infusion", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Hepatocellular carcinoma", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Hyperthermia", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Irinotecan", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Proton beam therapy", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Advanced hepatocellular carcinoma treated effectively with irinotecan via hepatic arterial infusion followed by proton beam therapy", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Advanced hepatocellular carcinoma treated effectively with irinotecan via hepatic arterial infusion followed by proton beam therapy"}]}, "item_type_id": "4", "owner": "3", "path": ["1763"], "permalink_uri": "http://hdl.handle.net/2297/19911", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-10-05"}, "publish_date": "2017-10-05", "publish_status": "0", "recid": "27011", "relation": {}, "relation_version_is_last": true, "title": ["Advanced hepatocellular carcinoma treated effectively with irinotecan via hepatic arterial infusion followed by proton beam therapy"], "weko_shared_id": -1}
Advanced hepatocellular carcinoma treated effectively with irinotecan via hepatic arterial infusion followed by proton beam therapy
http://hdl.handle.net/2297/19911
http://hdl.handle.net/2297/1991162b5e1ee-c0d1-45dc-b7ac-45523bf96cea
名前 / ファイル | ライセンス | アクション |
---|---|---|
HO-PR-OHTSUBO-K-316.pdf (130.1 kB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2017-10-05 | |||||
タイトル | ||||||
タイトル | Advanced hepatocellular carcinoma treated effectively with irinotecan via hepatic arterial infusion followed by proton beam therapy | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Ohtsubo, Koushiro
× Ohtsubo, Koushiro× Watanabe, Hiroyuki× Tsuchiyama, Tomoya× Mouri, Hisatsugu× Yamaguchi, Yasushi× Motoo, Yoshiharu× Okai, Takashi× Sanada, Junichiro× Matsui, Osamu× Kitamura, Tokuji× Fujiki, Ryusuke× Tokuuye, Koichi× Sawabu, Norio |
|||||
提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医学部附属病院がん高度先進治療センター | |||||
書誌情報 |
Journal of Infection and Chemotherapy 巻 15, 号 5, p. 316-321, 発行日 2009-10-01 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1341-321X | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11057978 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s10156-009-0702-z | |||||
出版者 | ||||||
出版者 | Springer Verlag (Germany) / 日本化学療法学会 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We report a 48-year-old man with hepatocellular carcinoma (HCC) treated with hepatic arterial infusion (HAI) chemotherapy followed by proton beam therapy. The HCC lesion in this patient was 88 mm in diameter, with portal vein tumor thrombosis in the right lobe of the liver. He was first treated with 5-fluorouracil, cisplatin, and isovorin, administered by HAI, combined with interferon-α, and he was subsequently treated with epirubicin and mitomycin-C administered by HAI. However, no definite efficacy of either of these treatments was observed. Then, after 3 weeks' continuous administration of irinotecan by HAI, the tumor size decreased to 68 mm in diameter. However, 3 months after reduction of the tumor, the tumor had become enlarged to 100 mm in diameter and intrahepatic metastases were prominent. Angiographic findings indicated that the HCC was fed not only from the right hepatic artery but also from the left gastric and right and left subphrenic arteries. After rearrangement of the arteries, and 3 months' continuous HAI chemotherapy with irinotecan, plus hyperthermia, the tumor size had decreased to 50 mm in diameter. The reduction rate of the main tumor according to the Response Evaluation Criteria in Solid Tumors was 43%; therefore, the efficacy of this treatment was judged as a partial response. Two months after reduction of the tumor, the patient's serum alpha-fetoprotein (AFP) level was elevated, and so docetaxel was administered by HAI instead of irinotecan. The liver tumors showed gradual enlargement during the administration of docetaxel, although the AFP level was suppressed. Proton beam therapy was instituted and the liver tumors showed necrosis after this therapy. The patient died of hepatic failure and distant metastases 6 years after the onset of HCC. As far as we know, this is the first case report of HCC treated effectively with irinotecan administered by HAI followed by proton beam therapy in which tumor suppression and the long-term survival of the patient were observed. © 2009 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa |