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Gemcitabine-induced CXCL8 expression counteracts its actions by inducing tumor neovascularization
http://hdl.handle.net/2297/41331
http://hdl.handle.net/2297/4133140b176a5-dea6-419b-a0ab-c611fe84a0e2
名前 / ファイル | ライセンス | アクション |
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CA-PR-MUKAIDA-N-341.pdf (348.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-05 | |||||
タイトル | ||||||
タイトル | Gemcitabine-induced CXCL8 expression counteracts its actions by inducing tumor neovascularization | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Song, Yao
× Song, Yao× Baba, Tomohisa× Li, Ying-Yi× Furukawa, Kaoru× Tanabe, Yamato× Matsugo, Seiichi× Sasaki, Soichiro× Mukaida, Naofumi |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | mukaida@staff.kanazawa-u.ac.jp | |||||
書誌情報 |
Biochemical and Biophysical Research Communications 巻 458, 号 2, p. 341-346, 発行日 2015-03-02 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0006-291X | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00564395 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.bbrc.2015.01.112 | |||||
出版者 | ||||||
出版者 | Academic Press | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Patients with pancreatic ductal adenocarcinoma (PDAC) are frequently complicated with metastatic disease or locally advanced tumors, and consequently need chemotherapy. Gemcitabine is commonly used for PDAC treatment, but with limited efficacy. The capacity of gemcitabine to generate reactive oxygen species (ROS) in human pancreatic cancer cells, prompted us to examine its effects on the expression of pro-inflammatory cytokines and chemokines. We observed that gemcitabine enhanced selectively the expression of CXCL8 in human pancreatic cancer cells through ROS generation and NF-κB activation. In vitro blocking of CXCL8 failed to modulate gemcitabine-mediated inhibition of cell proliferation in human pancreatic cancer cells. Gemcitabine also enhanced CXCL8 expression in pancreatic cancer cells in xenografted tumor tissues. Moreover, anti-CXCL8 antibody treatment in vivo attenuated tumor formation as well as intra-tumoral vascularity in nude mice, which were transplanted with Miapaca-2 cells and treated with gemcitabine. Thus, gemcitabine-induced CXCL8 may counteract the drug through inducing neovascularization. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa |