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Longitudinal analysis of serum interleukin-18 in patients with familial Mediterranean fever carrying MEFV mutations in exon 10
https://doi.org/10.24517/00049794
https://doi.org/10.24517/00049794118a4882-19cf-4816-abed-1206a59684bc
名前 / ファイル | ライセンス | アクション |
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HO-PR-WADA-T-143.pdf (100.8 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-05-07 | |||||
タイトル | ||||||
タイトル | Longitudinal analysis of serum interleukin-18 in patients with familial Mediterranean fever carrying MEFV mutations in exon 10 | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.24517/00049794 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Wada, Taizo
× Wada, Taizo× Toma, Tomoko× Miyazawa, Hanae× Koizumi, Eiko× Shirahashi, Tetsujiro× Matsuda, Yusuke× Yachie, Akihiro |
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著者別表示 |
和田, 泰三
× 和田, 泰三× 東馬, 智子× 小泉, 瑛子× 松田, 裕介× 谷内江, 昭宏 |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学附属病院小児科 | |||||
書誌情報 |
Cytokine 巻 104, p. 143-146, 発行日 2018-04-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1043-4666 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10794201 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.cyto.2017.10.007 | |||||
出版者 | ||||||
出版者 | Academic Press / Elsevier | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background: Familial Mediterranean fever (FMF) is an autoinflammatory disease caused by mutations in the MEFV gene. Mutations in exon 10 are associated with typical FMF phenotypes, and patients with exon 10 mutations have higher serum levels of interleukin (IL)-18 both during attacks and afebrile phases, compared to those without exon 10 mutations. However, longitudinal changes of serum IL-18 in FMF have not been fully characterized. Methods: We serially evaluated serum levels of pro-inflammatory cytokines, including IL-18, in 12 patients with FMF carrying exon 10 mutations, all of whom showed typical FMF attacks. Results: Markedly high concentrations of IL-18 were observed in all patients at diagnosis (5099. ±. 6084. pg/mL). Serum IL-18 levels declined progressively after colchicine treatment in 7 patients (group A), whereas 5 patients showed continued elevation of circulating IL-18, despite declines in IL-6 and neopterin (group B). The mean follow-up times in the two groups were 4.7. ±. 3.2 and 4.8. ±. 1.5 years, respectively. The mean serum IL-18 level at the last hospital visit in group B was 4190. ±. 2610[U+202F]pg/mL. There were no differences in onset age, initial IL-18 levels, and colchicine doses between the groups. FMF attacks almost disappeared in both groups, but there were trends towards more frequent subtle symptoms such as abdominal discomfort in group B. Conclusions: Sustained elevation of serum IL-18 may suggest the presence of persistent subclinical inflammation. Therefore, longitudinal examination of serum IL-18 may contribute to better follow-up of FMF patients with exon 10 mutations. © 2017 Elsevier Ltd. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Embargo Period 12 moths | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.elsevier.com/locate/issn/10434666 | |||||
関連名称 | http://www.elsevier.com/locate/issn/10434666 |