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Evaluation of effects of topical estradiol benzoate application on cutaneous wound healing in ovariectomized female mice
https://doi.org/10.24517/00050753
https://doi.org/10.24517/000507539501778e-608f-4152-ab5d-1a7c1c6585a6
名前 / ファイル | ライセンス | アクション |
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ME-PR-NAKATANI-T-0163560.pdf (2.3 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-05-17 | |||||
タイトル | ||||||
タイトル | Evaluation of effects of topical estradiol benzoate application on cutaneous wound healing in ovariectomized female mice | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.24517/00050753 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Mukai, Kanae
× Mukai, Kanae× Urai, Tamae× Asano, Kimi× Nakajima, Yukari× Nakatani, Toshio |
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著者別表示 |
向井, 加奈恵
× 向井, 加奈恵× 中島, 由加里× 中谷, 壽男 |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医薬保健研究域 | |||||
書誌情報 |
en : PLoS ONE 巻 11, 号 9, p. e0163560, 発行日 2016-09-22 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1932-6203 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1371/journal.pone.0163560 | |||||
出版者 | ||||||
出版者 | Public Library of Science | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Estrogen promotes cutaneous wound healing in ovariectomized (OVX) female mice. However, the effects of topical estrogen application on wounds remain unclear. Therefore, the aim of this study was to compare the effects of topical estrogen application on wounds with standard treatment methods. Eight-week-old C57BL/6J female mice underwent OVX and received two full-thickness wounds four weeks later. Mice were divided into three groups: topical estradiol benzoate (EB) (0.75 μg/g/day) wound treatment, subcutaneous estradiol (E2) pellets (0.05 mg, 21 days), and topical E2 (0.01 g/day) skin application. Wound healing was observed until day 14. Wound area ratios were significantly smaller in the topical EB wound treatment group than in the subcutaneous E2 pellet group on days 1-14 (p < 0.05) and topical E2 skin application group on days 1-9 (p < 0.05). Neutrophil and macrophage numbers were significantly smaller in the topical EB wound treatment group than in the subcutaneous E2 pellet and topical E2 skin application groups on day 7 (p < 0.05). Moreover, the number of new blood vessels and ratio of myofibroblasts were significantly larger in the topical EB wound treatment group than in the subcutaneous E2 pellet and topical E2 application skin groups on day 7 (p < 0.05). These results demonstrate that the application of estrogen to wounds reduced inflammatory responses and promoted angiogenesis and wound contraction more than the two other standard treatment methods. � 2016 Mukai et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |||||
権利 | ||||||
権利情報 | Copyright © Public Library of Science | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0163560 | |||||
関連名称 | http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0163560 |