Establishment of diagnostic method, evaluation of pathological conditions and elucidation of refractory factors in chronic cough using exhaled breath condensate
本邦では人口の2%が8週間以上の慢性咳嗽を有する．執拗な咳嗽は生活の質を低下させ，患者を疲弊させる．病名を正しく診断するための検査は特殊であり，一部の医療機関においてしか実施できない．正しい診断が出来なければ，正しい治療も出来ない．どの医療機関でも非侵襲的に繰り返し採取できる呼気凝縮液に含まれる脂質mediatorの測定が慢性咳嗽の原因診断に繋がることを期待し研究を開始した．しかし，呼気凝縮中の脂質mediatorを再現性良く測定することはできなかったため，検体を血液と尿に変更し検討を行った．数種類の脂質mediatorが測定でき，慢性咳嗽の疾患毎に一定の傾向を示す可能性があることが分かった．
In Japan, 2% of the population has chronic cough for 8 weeks or longer. Relentless cough reduces quality of life and exhausts patients. Tests for correctly diagnosing the name of a disease are special and can only be performed at some medical institutions. If you cannot make a correct diagnosis, you cannot make a correct treatment. We started the study with the expectation that the measurement of lipid mediator contained in exhaled condensate, which can be collected repeatedly non-invasively at any medical institution, will lead to the diagnosis of the cause of chronic cough. However, since the lipid mediator during exhalation condensation could not be measured with good reproducibility, the samples were changed to blood and urine for examination. Several types of lipid mediators could be measured, and it was found that there is a possibility that a certain tendency is shown for each disease of chronic cough.
呼気凝縮液を用いた慢性咳嗽の診断法の確立，病態評価，難治化因子の解明
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ME-PR-HARA-J-kaken 2021-5p.pdf
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