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Selenium Compound Protects Corneal Epithelium against Oxidative Stress
https://doi.org/10.24517/00062815
https://doi.org/10.24517/000628150d8cf05a-635b-4679-93a3-3314c97ae0cc
名前 / ファイル | ライセンス | アクション |
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FR-PR-HIGUCHI-A- e45612.pdf (277.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-07-05 | |||||
タイトル | ||||||
タイトル | Selenium Compound Protects Corneal Epithelium against Oxidative Stress | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.24517/00062815 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Higuchi, Akihiro
× Higuchi, Akihiro× Inoue, Hiroyoshi× Kawakita, Tetsuya× Ogishima, Tadashi× Tsubota, Kazuo |
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著者別表示 |
樋口, 明弘
× 樋口, 明弘 |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学先端科学・社会共創推進機構 | |||||
書誌情報 |
PLoS ONE 巻 7, 号 9, p. e45612, 発行日 2012-09-25 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1932-6203 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1371/journal.pone.0045612 | |||||
出版者 | ||||||
出版者 | Public Library of Science | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The ocular surface is strongly affected by oxidative stress, and anti-oxidative systems are maintained in corneal epithelial cells and tear fluid. Dry eye is recognized as an oxidative stress-induced disease. Selenium compound eye drops are expected to be a candidate for the treatment of dry eye. We estimated the efficacy of several selenium compounds in the treatment of dry eye using a dry eye rat model. All of the studied selenium compounds were uptaken into corneal epithelial cells in vitro. However, when the selenium compounds were administered as eye drops in the dry eye rat model, most of the selenium compounds did not show effectiveness except for Se-lactoferrin. Se-lactoferrin is a lactoferrin that we prepared that binds selenium instead of iron. Se-lactoferrin eye drops suppressed the up-regulated expression of heme oxygenase-1, cyclooxygenase-2, matrix metallopeptidase-9, and interleukin-6 and also suppressed 8-OHdG production in the cornea induced by surgical removal of the lacrimal glands. Compared with Se-lactoferrin, apolactoferrin eye drops weakly improved dry eye in high dose. The effect of Se-lactoferrin eye drops on dry eye is possibly due to the effect of selenium and also the effect of apolactoferrin. Se-lactoferrin is a candidate for the treatment of dry eye via regulation of oxidative stress in the corneal epithelium. © 2012 Higuchi et al. | |||||
権利 | ||||||
権利情報 | Copyright © Public Library of Science | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.plosone.org/ | |||||
関連名称 | http://www.plosone.org/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0045612 | |||||
関連名称 | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0045612 |