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交流磁場を用いた抗がん剤の標的治療技術の開発
https://doi.org/10.24517/00034477
https://doi.org/10.24517/00034477504b2b62-488a-4cb0-a4c2-dc5f78872d15
名前 / ファイル | ライセンス | アクション |
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TE-PR-KAKIKAWA-M-kaken 2015-5p.pdf (165.2 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2017-10-05 | |||||
タイトル | ||||||
タイトル | 交流磁場を用いた抗がん剤の標的治療技術の開発 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Development of targeted techniques of anticancer drug using magnetic fields | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00034477 | |||||
ID登録タイプ | JaLC | |||||
著者別表示 |
Kakikawa, Makiko
× Kakikawa, Makiko |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学環日本海域環境研究センター | |||||
書誌情報 |
平成26(2014)年度 科学研究費補助金 基盤研究(C) 研究成果報告書 en : 2014 Fiscal Year Final Research Report 巻 2012-04-01 – 2015-03-31, p. 5p., 発行日 2015-06-09 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 大腸菌の実験系では、交流磁場曝露により薬剤作用が増強される結果が得られており、本研究ではヒトがん細胞における交流磁場曝露の薬剤作用への効果を検討するため、まずCO2インキュベータ内に設置できる磁場曝露システムを製作した。その装置を用いてヒト肺がん細胞株A549におけるシスプラチン作用への交流磁場影響を測定したところ、磁場曝露群(60 Hz, 50 mT, 24時間)は非曝露群に比べ生細胞数が減少し、磁場による薬剤作用の増強が認められた。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Our results in previous study indicated that magnetic fields (60 Hz, 50 mT) enhance the potency of drugs in bacterial cells and suggested that magnetic fields change the permeability of cell membrane and increase drug uptake. If magnetic fields enable us to enhance the potency of anticancer drug on target region only, the dosage can be reduced and thus side effects can be suppressed in clinical cancer chemotherapy. In present study, we made a magnetic fields exposure system for cultured human cells and measured the effect of magnetic fields on a potency of anticancer drug, cisplatin to human lung cancer cell line. The viabilities of A549 cells treated with cisplatin only and cisplatin under magnetic fields exposure (60 Hz, 50 mT for 24 hours) were measured by colony assay. The result suggested that magnetic fields (60 Hz, 50 mT for 24 hours) enhance the potency of cisplatin on human cancer cells. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:24500541, 研究期間(年度):2012-04-01 – 2015-03-31 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:研究課題「交流磁場を用いた抗がん剤の標的治療技術の開発」課題番号24500541 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24500541/24500541seika/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=10359713 | |||||
関連名称 | https://kaken.nii.ac.jp/search/?qm=10359713 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24500541/ | |||||
関連名称 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24500541/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24500541/24500541seika/ | |||||
関連名称 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24500541/24500541seika/ |