WEKO3
インデックスリンク
アイテム
{"_buckets": {"deposit": "be003388-6d9c-434b-82b1-6b23d9213c59"}, "_deposit": {"created_by": 18, "id": "44234", "owners": [18], "pid": {"revision_id": 0, "type": "depid", "value": "44234"}, "status": "published"}, "_oai": {"id": "oai:kanazawa-u.repo.nii.ac.jp:00044234", "sets": ["2823"]}, "author_link": ["74393", "74392"], "item_9_biblio_info_8": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2011-05-09", "bibliographicIssueDateType": "Issued"}, "bibliographicPageStart": "5p.", "bibliographicVolumeNumber": "2008-2010", "bibliographic_titles": [{"bibliographic_title": "平成22(2010)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"}, {"bibliographic_title": "2010 Fiscal Year Final Research Report", "bibliographic_titleLang": "en"}]}]}, "item_9_creator_33": {"attribute_name": "著者別表示", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Yasumoto, Kazuo"}], "nameIdentifiers": [{"nameIdentifier": "74393", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "90262592", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=90262592"}]}]}, "item_9_description_21": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "これまでのわれわれの検討から胃癌癌性腹膜炎発症進展におけるCXCR4/CXCL12 axisの関与が明らかとなった。そこで本研究では、癌性腹水中に存在する癌細胞増殖因子、とくにEGFR ligand axisに着目した。本研究結果から、癌性腹水中にはEGFRリガンド中でamphiregulin、HB-EGFが多量に存在し、CXCR4発現胃癌細胞(EGFR高発現)に対して強力な細胞増殖作用を有すること、すなわちEGFR/EGFR ligand axis (amphiregulin, HB-EGF)が、胃癌性腹膜炎形成に重要な役割を果たし、CXCR4/CXCL12 axisとの相互促進作用を介して、本病態の発症進展に深く関与することを初めて明らかにした(Clin Cancer Res 2011 in press)。", "subitem_description_type": "Abstract"}, {"subitem_description": "In this study, we showed that the EGFR ligands, amphiregulin and HB-EGF, are abundant in malignant ascites. Amphiregulin strongly enhanced the proliferation of CXCR4-expressing human gastric cancer NUGC4 cells, whereas HB-EGF markedly induced migration of fibroblasts. Moreover, HB-EGF and CXCL12 together enhanced TNF□-converting enzyme (TACE)-dependent amphiregulin shedding from functional CXCR4-expressing NUGC4 cells. Cetuximab, an anti-EGFR monoclonal antibody, effectively reduced tumor growth and ascites formation, and therefore dramatically prolonged survival in nude mice inoculated with NUGC4 cells. Our findings provide a novel insight into treatments that target tumor cells and their microenvironments during the development of peritoneal carcinomatosis from gastric cancer (Clin Cancer Res 2011 in press).", "subitem_description_type": "Abstract"}]}, "item_9_description_22": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "出典:研究課題「CXCR4/CXCL12とHB-EGFを標的とした胃癌標的治療法の開発」課題番号20591565\n(KAKEN:科学研究費助成事業データベース(国立情報学研究所)) \n(https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20591565/20591565seika/)を加工して作成", "subitem_description_type": "Other"}]}, "item_9_description_5": {"attribute_name": "提供者所属", "attribute_value_mlt": [{"subitem_description": "金沢大学がん進展制御研究所", "subitem_description_type": "Other"}]}, "item_9_identifier_registration": {"attribute_name": "ID登録", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.24517/00050576", "subitem_identifier_reg_type": "JaLC"}]}, "item_9_relation_28": {"attribute_name": "関連URI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://kaken.nii.ac.jp/search/?qm=90262592", "subitem_relation_type_select": "URI"}}, {"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591565/", "subitem_relation_type_select": "URI"}}, {"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20591565/20591565seika/", "subitem_relation_type_select": "URI"}}]}, "item_9_version_type_25": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "安本, 和生"}], "nameIdentifiers": [{"nameIdentifier": "74392", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "90262592", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=90262592"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-04-19"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "CA-PR-YASUMOTO-K-kaken 2011-5p.pdf", "filesize": [{"value": "211.1 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 211100.0, "url": {"label": "CA-PR-YASUMOTO-K-kaken 2011-5p.pdf", "url": "https://kanazawa-u.repo.nii.ac.jp/record/44234/files/CA-PR-YASUMOTO-K-kaken 2011-5p.pdf"}, "version_id": "62cd69e1-d429-47e1-a793-b5f39d582928"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "胃十二指腸外科学", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "research report", "resourceuri": "http://purl.org/coar/resource_type/c_18ws"}]}, "item_title": "CXCR4/CXCL12とHB-EGFを標的とした胃癌標的治療法の開発", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "CXCR4/CXCL12とHB-EGFを標的とした胃癌標的治療法の開発"}, {"subitem_title": "Development of molecular target therapy for gastric cancer targeted for the CXCR4/CXCL12 axis and HB-EGF", "subitem_title_language": "en"}]}, "item_type_id": "9", "owner": "18", "path": ["2823"], "permalink_uri": "https://doi.org/10.24517/00050576", "pubdate": {"attribute_name": "公開日", "attribute_value": "2018-04-20"}, "publish_date": "2018-04-20", "publish_status": "0", "recid": "44234", "relation": {}, "relation_version_is_last": true, "title": ["CXCR4/CXCL12とHB-EGFを標的とした胃癌標的治療法の開発"], "weko_shared_id": -1}
CXCR4/CXCL12とHB-EGFを標的とした胃癌標的治療法の開発
https://doi.org/10.24517/00050576
https://doi.org/10.24517/000505762f4e30ad-c016-4937-b28e-d4f9d65a56db
名前 / ファイル | ライセンス | アクション |
---|---|---|
CA-PR-YASUMOTO-K-kaken 2011-5p.pdf (211.1 kB)
|
Item type | 報告書 / Research Paper(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2018-04-20 | |||||
タイトル | ||||||
タイトル | CXCR4/CXCL12とHB-EGFを標的とした胃癌標的治療法の開発 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Development of molecular target therapy for gastric cancer targeted for the CXCR4/CXCL12 axis and HB-EGF | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00050576 | |||||
ID登録タイプ | JaLC | |||||
著者別表示 |
Yasumoto, Kazuo
× Yasumoto, Kazuo |
|||||
提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学がん進展制御研究所 | |||||
書誌情報 |
平成22(2010)年度 科学研究費補助金 基盤研究(C) 研究成果報告書 en : 2010 Fiscal Year Final Research Report 巻 2008-2010, p. 5p., 発行日 2011-05-09 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | これまでのわれわれの検討から胃癌癌性腹膜炎発症進展におけるCXCR4/CXCL12 axisの関与が明らかとなった。そこで本研究では、癌性腹水中に存在する癌細胞増殖因子、とくにEGFR ligand axisに着目した。本研究結果から、癌性腹水中にはEGFRリガンド中でamphiregulin、HB-EGFが多量に存在し、CXCR4発現胃癌細胞(EGFR高発現)に対して強力な細胞増殖作用を有すること、すなわちEGFR/EGFR ligand axis (amphiregulin, HB-EGF)が、胃癌性腹膜炎形成に重要な役割を果たし、CXCR4/CXCL12 axisとの相互促進作用を介して、本病態の発症進展に深く関与することを初めて明らかにした(Clin Cancer Res 2011 in press)。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In this study, we showed that the EGFR ligands, amphiregulin and HB-EGF, are abundant in malignant ascites. Amphiregulin strongly enhanced the proliferation of CXCR4-expressing human gastric cancer NUGC4 cells, whereas HB-EGF markedly induced migration of fibroblasts. Moreover, HB-EGF and CXCL12 together enhanced TNF□-converting enzyme (TACE)-dependent amphiregulin shedding from functional CXCR4-expressing NUGC4 cells. Cetuximab, an anti-EGFR monoclonal antibody, effectively reduced tumor growth and ascites formation, and therefore dramatically prolonged survival in nude mice inoculated with NUGC4 cells. Our findings provide a novel insight into treatments that target tumor cells and their microenvironments during the development of peritoneal carcinomatosis from gastric cancer (Clin Cancer Res 2011 in press). | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:研究課題「CXCR4/CXCL12とHB-EGFを標的とした胃癌標的治療法の開発」課題番号20591565 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20591565/20591565seika/)を加工して作成 |
|||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=90262592 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591565/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20591565/20591565seika/ |