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抗癌剤および血管新生阻害剤による口腔扁平上皮癌の浸潤・転移抑制効果
https://doi.org/10.24517/00050674
https://doi.org/10.24517/000506746e2f3902-e8ee-4a43-98e6-764336ba19bf
名前 / ファイル | ライセンス | アクション |
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HO-PR-KAWASHIRI-S-kaken 2011-6p.pdf (226.1 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2018-05-07 | |||||
タイトル | ||||||
タイトル | 抗癌剤および血管新生阻害剤による口腔扁平上皮癌の浸潤・転移抑制効果 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Effects of anticancer drug and angiogenesis inhibitor on invasion and metastasis of oral squamous cell carcinoma | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00050674 | |||||
ID登録タイプ | JaLC | |||||
著者別表示 |
Kawashiri, Shuichi
× Kawashiri, Shuichi |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医薬保健研究域医学系 | |||||
書誌情報 |
平成22(2010)年度 科学研究費補助金 基盤研究(C) 研究成果報告書 en : 2010 Fiscal Year Final Research Report 巻 2008-2010, p. 6p., 発行日 2011-05-18 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 口腔扁平上皮癌の臨床での浸潤および転移を忠実に再現できるマウス正所性移植モデルを用いて、抗癌剤と血管新生阻害剤の効果を検討した。癌細胞は高浸潤高転移性のヒトロ腔扁平上皮癌細胞株であるOSC-19細胞を使用し、ヌードマウスの口腔底もしくは舌に移植した。抗癌剤はシスプラチンを血管新生阻害薬はトラニラストを用いて、浸潤と転移の阻止効果を調べた。その結果、腫瘍の大きさ、浸潤様式のダウングレード、リンパ節転移にそれぞれ効果を認め、臨床的にも有意義であると考えられた。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Using an orthotopic implantation mice model in which the invasion and metastasis of oral cancer can be reproduced, we investigated the inhibitory effects of anticancer agent and angiogenesis inhibitor on invasion and metastasis. A highly invasive and metastatic human oral squamous cell carcinoma cell line, OSC-19, was implanted into the tongue or oral floor of nude mice, and cisplatin or tranilast were administered to the mice after the implantation. The effects of each drug on cancer invasion and metastasiswere investigated. Tumor size and the ratio of proliferating cell nuclear antigen positive cells were significantly reduced. In the control group, the tumors showed grade 4C of mode of invasion, while in the groups treated with anticancer agent and angiogenesis inhibitor, grade 3 was observed, with an inhibitory effect on tumor invasion being observed. The rate of metastasis in the cervical lymph node was significantly decreased in the groups treated with the anticancer agent and angiogenesis inhibitor. The tumor stage progression in the metastatic lymph nodes was also inhibited. The use of anticancer agent and angiogenesis inhibitor considering these effects may be clinically very useful. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:研究課題「抗癌剤および血管新生阻害剤による口腔扁平上皮癌の浸潤・転移抑制効果」課題番号20592357 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20592357/20592357seika/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=30291371 | |||||
関連名称 | https://kaken.nii.ac.jp/search/?qm=30291371 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20592357/ | |||||
関連名称 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20592357/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20592357/20592357seika/ | |||||
関連名称 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20592357/20592357seika/ |