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肺癌に対する体外肺切除における、気管支創傷治癒へのキトサンナノ繊維シートの効果
https://doi.org/10.24517/00050701
https://doi.org/10.24517/00050701da67185b-476a-40ac-914e-e1b8826a6bf6
名前 / ファイル | ライセンス | アクション |
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HO-PR-MATSUMOTO-I-kaken 2015-4p.pdf (331.4 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2018-05-11 | |||||
タイトル | ||||||
タイトル | 肺癌に対する体外肺切除における、気管支創傷治癒へのキトサンナノ繊維シートの効果 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | The efficacy of chitosan sheet covering for bronchial anastomosis wound healing in extracorporeal lung resection for lung cancer | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00050701 | |||||
ID登録タイプ | JaLC | |||||
著者別表示 |
Matsumoto, Isao
× Matsumoto, Isao |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医薬保健研究域医学系 | |||||
書誌情報 |
平成26(2014)年度 科学研究費補助金 基盤研究(C) 研究成果報告書 en : 2014 Fiscal Year Final Research Report 巻 2012-04-01 - 2015-03-31, p. 4p., 発行日 2015-05-27 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 【目的】肺癌に対する「体外肺切除」における、キトサンシートの気管支吻合部創傷治癒への効果と安全性について検証。【対象と方法】犬で体外肺切除モデルを作成し、気管支吻合部被覆を①対照群:被覆なし、②C群:キトサンシート被覆、③M群:肋間筋被覆、に分け比較。【結果】対照群1頭は気管支縫合不全、膿胸で死亡。他は全頭犠牲死まで合併症なく生存。気管支吻合部組織血流、気管支吻合部の炎症改善、胸部Xpでの肺水腫改善において、いずれもC群が最も良好。気管支吻合部外側の肉芽・血管新生はM群>C群>対照群。【結語】体外肺切除の気管支吻合において、キトサンシート被覆は安全に創傷治癒を促進し、肋間筋被覆よりも有用。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Aim: We investigated the efficacy and safety of chitosan sheet covering for bronchial anastomosis wound healing in "extracorporeal lung resection (ECLR)" for lung cancer. Materials and methods: ECLR model was prepared and applied to dogs in control group (no covering), C group (chitosan sheet covering), and M group (intercostal muscle covering). Bronchial anastomotic site healing statuses were compared among the groups. Results: One dog of the control group died due to bronchial fistula accompanying empyema. All other dogs survived with no complication. C group had the highest recovery in tissue blood flow of bronchial anastomotic site, inflammation improvement of anastomotic site, and lung edema improvement on chest X-ray films. Granulation and angiogenesis around the anastomotic site were promoted the most in M group followed by C group and then the control group. Conclusion: For bronchial anastomosis wound healing in ECLR, chitosan sheet covering is safe and promotes wound healing. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:24592085, 研究期間(年度):2012-04-01 - 2015-03-31 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:研究課題「肺癌に対する体外肺切除における、気管支創傷治癒へのキトサンナノ繊維シートの効果」課題番号24592085 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24592085/24592085seika/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=80361989 | |||||
関連名称 | https://kaken.nii.ac.jp/search/?qm=80361989 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24592085/ | |||||
関連名称 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24592085/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24592085/24592085seika/ | |||||
関連名称 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24592085/24592085seika/ |