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Oral Fat Tolerance Test for Sitosterolemia and Familial Hypercholesterolemia: A Study Protocol
https://doi.org/10.24517/00053010
https://doi.org/10.24517/00053010e1d0296c-53b9-4054-b958-5a8120cba690
名前 / ファイル | ライセンス | アクション |
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ME-PR-TADA-H-741.pdf (148.8 kB)
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Item type | 学術雑誌論文 / Journal Article_04(1) | |||||
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公開日 | 2019-01-07 | |||||
タイトル | ||||||
タイトル | Oral Fat Tolerance Test for Sitosterolemia and Familial Hypercholesterolemia: A Study Protocol | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.24517/00053010 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Nomura, Akihiro
× Nomura, Akihiro× Tada, Hayato× Nohara, Atsushi× Kawashiri, Masa-aki× Yamagishi, Masakazu |
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著者別表示 |
野村, 章洋
× 野村, 章洋× 多田, 隼人× 野原, 淳× 川尻, 剛照× 山岸, 正和 |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学附属病院先端医療開発センター | |||||
書誌情報 |
Journal of Atherosclerosis and Thrombosis 巻 25, 号 8, p. 741-746, 発行日 2018 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1340-3478 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11018976 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.5551/jat.42960 | |||||
出版者 | ||||||
出版者 | 日本動脈硬化学会 = Japan Atherosclerosis Society | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Aim: Sitosterolemia is an extremely rare, autosomal recessive disease characterized by high plasma cholesterols and plant sterols because of increased absorption of dietary cholesterols and sterols from the intestine, and decreased excretion from biliary tract. Previous study indicated that sitosterolemic patients might be vulnerable to post-prandial hyperlipidemia, including high remnant-like lipoprotein particles (RLP) level. Here we evaluate whether a loading dietary fat increases a post-prandial RLP cholesterol level in sitosterolemic patients compared to heterozygous familial hypercholesterolemic patients (FH). \nMethods: We recruit total of 20 patients: 5 patients with homozygous sitosterolemia, 5 patients with heterozygous sitosterolemia, and 10 patients with heterozygous FH as controls from May 2015 to March 2018 at Kanazawa University Hospital, Japan. All patients receive Oral Fat Tolerance Test (OFTT) cream (50 g/body surface area square meter, orally only once, and the cream includes 34% of fat, 74 mg of cholesterol, and rich in palmitic and oleic acids. The primary endpoint is the change of a RLP cholesterol level after OFTT cream loading between sitosterolemia and FH. We measure them at baseline, and 2, 4, and 6 hours after the oral fat loading. \nResults: This is the first study to evaluate whether sitosterolemia patients have a higher post-prandial RLP cholesterol level compared to heterozygous FH patients. \nConclusion: The result may become an additional evidence to restrict dietary cholesterols for sitosterolemia. This study is registered at University Hospital Medical Information Network (UMIN) Clinical Trials Registry (UMIN ID: UMIN000020330). |
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内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | This article distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License. | |||||
権利 | ||||||
権利情報 | Copyright © 日本動脈硬化学会 Japan Atherosclerosis Society | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.jstage.jst.go.jp/browse/jat/-char/ja | |||||
関連名称 | https://www.jstage.jst.go.jp/browse/jat/-char/ja | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.j-athero.org/ | |||||
関連名称 | http://www.j-athero.org/ |