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Blockade of the chemokine receptor, CCR5, reduces the growth of orthotopically injected colon cancer cells via limiting cancer-associated fibroblast accumulation
https://doi.org/10.24517/00061538
https://doi.org/10.24517/000615385b025863-3430-4d9b-a46b-cd52784eb219
名前 / ファイル | ライセンス | アクション |
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CA-PR-MUKAIDA-N-48335.pdf (5.4 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-03-26 | |||||
タイトル | ||||||
タイトル | Blockade of the chemokine receptor, CCR5, reduces the growth of orthotopically injected colon cancer cells via limiting cancer-associated fibroblast accumulation | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.24517/00061538 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Tanabe, Yamato
× Tanabe, Yamato× Sasaki, Soichiro× Mukaida, Naofumi× Baba, Tomohisa |
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著者別表示 |
佐々木, 宗一郎
× 佐々木, 宗一郎× 向田, 直史× 馬場, 智久 |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学がん進展制御研究所 | |||||
書誌情報 |
Oncotarget 巻 7, 号 30, p. 48335-48345, 発行日 2016-07 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1949-2553 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.18632/oncotarget.10227 | |||||
出版者 | ||||||
出版者 | Impact Journals LLC | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We previously demonstrated that cancer-associated fibroblasts (CAFs) accumulate at tumor sites through the interaction between a chemokine, CCL3, and its receptor, CCR5, in the late phase of colitis-associated colon carcinogenesis. Here we examined the effect of a CCR5 antagonist, maraviroc, on tumor growth arising from the orthotopic injection of mouse or human colon cancer cell lines into the cecal wall by focusing on CAFs. Orthotopic injection of either cell line caused tumor formation together with leukocyte infiltration and fibroblast accumulation. Concomitant oral administration of maraviroc reduced tumor formation with few effects on leukocyte infiltration. In contrast, maraviroc reduced the intratumor number of α-smooth muscle actin-positive fibroblasts, which express epidermal growth factor, a crucial growth factor for colon cancer cell growth. These observations suggest that maraviroc or other CCR5 antagonists might act as novel anti-CRC drugs to dampen CAFs, an essential cell component for tumor progression. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | This work was supported by a Grant-in-Aid for Young Scientists (B) 15K18406 from the Japan Society for the Promotion of Science (JSPS). | |||||
権利 | ||||||
権利情報 | Copyright © Authors. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.impactjournals.com/oncotarget/ | |||||
関連名称 | http://www.impactjournals.com/oncotarget/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.oncotarget.com/article/10227/text/ | |||||
関連名称 | https://www.oncotarget.com/article/10227/text/ |