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Isolation of tissue-resident endothelial stem cells and their use in regenerative medicine
https://doi.org/10.24517/00062981
https://doi.org/10.24517/0006298125d73077-ccc1-406f-9d3f-8b8931908517
名前 / ファイル | ライセンス | アクション |
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ME-PR-NAITO-H-0098-9.pdf (7.9 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-07-05 | |||||
タイトル | ||||||
タイトル | Isolation of tissue-resident endothelial stem cells and their use in regenerative medicine | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.24517/00062981 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Iba, Tomohiro
× Iba, Tomohiro× Naito, Hisamichi× Shimizu, Shota× Rahmawati, Fitriana Nur× Wakabayashi, Taku× Takakura, Nobuyuki |
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著者別表示 |
内藤, 尚道
× 内藤, 尚道× 高倉, 伸幸 |
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書誌情報 |
Inflammation and Regeneration 巻 39, 号 1, p. 9, 発行日 2019-05-08 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1880-8190 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1186/s41232-019-0098-9 | |||||
出版者 | ||||||
出版者 | BioMed Central Ltd. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background: During sprouting angiogenesis, stalk cells, localized behind tip cells, generate endothelial cells (ECs) for the elongation of new vessels. We hypothesized that stalk cells may have endothelial progenitor cell properties because of their highly proliferative ability. We conducted Hoechst dye DNA staining in ECs of preexisting blood vessels from hind limb muscle and found that endothelial-side population (E-SP) cells, which efflux Hoechst rapidly with abundant ABC transporters, show highly producing ability of ECs. We previously showed the existence of E-SP cells in hind limb muscle, retina, and liver, but not in other tissues such as adipose tissue, skin, and placenta. Methods: We investigated the existence of E-SP cells and analyzed their proliferative ability among CD31+CD45- ECs from adipose tissue, skin, and placenta of adult mice. We also analyzed the neovascular formation of E-SP cells from adipose tissue in vivo. Results: We detected E-SP cells in all tissues examined. However, by in vitro colony formation analysis on OP9 cells, we found that E-SP cells from adipose tissue and skin, but not from placenta, have highly proliferative ability. Moreover, E-SP cells from adipose tissue could contribute to the neovascular formation in hind limb ischemia model. Conclusion: The adipose tissue and skin are available sources to obtain endothelial stem cells for conducting therapeutic angiogenesis in regenerative medicine. © 2019 The Author(s). | |||||
権利 | ||||||
権利情報 | copyright © BMC | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://inflammregen.biomedcentral.com/ | |||||
関連名称 | https://inflammregen.biomedcentral.com/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://inflammregen.biomedcentral.com/articles/10.1186/s41232-019-0098-9 | |||||
関連名称 | https://inflammregen.biomedcentral.com/articles/10.1186/s41232-019-0098-9 |