WEKO3
インデックスリンク
アイテム
{"_buckets": {"deposit": "c7e14833-c395-4aa6-8f1b-3e17ad3fd3aa"}, "_deposit": {"created_by": 18, "id": "56714", "owners": [18], "pid": {"revision_id": 0, "type": "depid", "value": "56714"}, "status": "published"}, "_oai": {"id": "oai:kanazawa-u.repo.nii.ac.jp:00056714", "sets": ["1134"]}, "author_link": ["99322", "99320", "99317", "23370", "95459", "97907", "99323", "99321", "99319", "99324", "15659", "99318", "99305"], "item_4_biblio_info_8": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2017-09-06", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageStart": "10613", "bibliographicVolumeNumber": "7", "bibliographic_titles": [{"bibliographic_title": "Scientific Reports"}]}]}, "item_4_creator_33": {"attribute_name": "著者別表示", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "内藤, 尚道"}], "nameIdentifiers": [{"nameIdentifier": "97907", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "30570676", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=30570676"}]}, {"creatorNames": [{"creatorName": "高倉, 伸幸"}], "nameIdentifiers": [{"nameIdentifier": "95459", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "80291954", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=80291954"}]}]}, "item_4_description_21": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Alterations to the tumor stromal microenvironment induced by chemotherapy could influence the behavior of cancer cells. In the tumor stromal microenvironment, cancer-associated fibroblasts (CAFs) play an important role. Because the receptor tyrosine kinase Axl and its ligand Gas6 could be involved in promoting non-small cell lung cancer (NSCLC), we investigated the role of Gas6 secreted by CAFs during chemotherapy in NSCLC. In a murine model, we found that Gas6 expression by CAFs was upregulated following cisplatin treatment. Gas6 expression might be influenced by intratumoral hypoperfusion during chemotherapy, and it increased after serum starvation in a human lung CAF line, LCAFhTERT. Gas6 is associated with LCAFhTERT cell growth. Recombinant Gas6 promoted H1299 migration, and conditioned medium (CM) from LCAFhTERT cells activated Axl in H1299 cells and promoted migration. Silencing Gas6 in LCAFhTERT reduced the Axl activation and H1299 cell migration induced by CM from LCAFhTERT. In clinical samples, stromal Gas6 expression increased after chemotherapy. Five-year disease-free survival rates for patients with tumor Axl- and stromal Gas6-positive tumors (n = 37) was significantly worse than for the double negative group (n = 12) (21.9% vs 51.3%, p = 0.04). Based on these findings, it is presumed that Gas6 derived from CAFs promotes migration of Axl-expressing lung cancer cells during chemotherapy and is involved in poor clinical outcome. © 2017 The Author(s).", "subitem_description_type": "Abstract"}]}, "item_4_description_5": {"attribute_name": "提供者所属", "attribute_value_mlt": [{"subitem_description": "金沢大学医薬保健研究域医学系", "subitem_description_type": "Other"}]}, "item_4_identifier_registration": {"attribute_name": "ID登録", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.24517/00062988", "subitem_identifier_reg_type": "JaLC"}]}, "item_4_publisher_17": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Nature Research / Nature Publishing Group"}]}, "item_4_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1038/s41598-017-10873-2", "subitem_relation_type_select": "DOI"}}]}, "item_4_relation_28": {"attribute_name": "関連URI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "http://www.nature.com/srep/index.html"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.nature.com/srep/index.html", "subitem_relation_type_select": "URI"}}, {"subitem_relation_name": [{"subitem_relation_name_text": "https://www.nature.com/articles/s41598-017-10873-2"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.nature.com/articles/s41598-017-10873-2", "subitem_relation_type_select": "URI"}}]}, "item_4_rights_23": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "copyright © Nature Research"}]}, "item_4_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2045-2322", "subitem_source_identifier_type": "ISSN"}]}, "item_4_version_type_25": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Ryu Kanzaki, "}], "nameIdentifiers": [{"nameIdentifier": "99317", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Naito, Hisamichi"}], "nameIdentifiers": [{"nameIdentifier": "97907", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "30570676", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=30570676"}]}, {"creatorNames": [{"creatorName": "Kise, Kazuyoshi"}], "nameIdentifiers": [{"nameIdentifier": "99318", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takara, Kazuhiro"}], "nameIdentifiers": [{"nameIdentifier": "99305", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Eino, Daisuke"}], "nameIdentifiers": [{"nameIdentifier": "99319", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Minami, Masato"}], "nameIdentifiers": [{"nameIdentifier": "99320", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shintani, Yasushi"}], "nameIdentifiers": [{"nameIdentifier": "99321", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Funaki, Soichiro"}], "nameIdentifiers": [{"nameIdentifier": "99322", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kawamura, Tomohiro"}], "nameIdentifiers": [{"nameIdentifier": "99323", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kimura, Toru"}], "nameIdentifiers": [{"nameIdentifier": "23370", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Okumura, Meinoshin"}], "nameIdentifiers": [{"nameIdentifier": "99324", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takakura, Nobuyuki"}], "nameIdentifiers": [{"nameIdentifier": "15659", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "80291954", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=80291954"}, {"nameIdentifier": "80291954", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000080291954"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2021-07-05"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "ME-PR-NAITO-H-10613.pdf", "filesize": [{"value": "4.2 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 4200000.0, "url": {"label": "ME-PR-NAITO-H-10613.pdf", "url": "https://kanazawa-u.repo.nii.ac.jp/record/56714/files/ME-PR-NAITO-H-10613.pdf"}, "version_id": "70a33fd0-24c9-4c43-b2e8-0f61871bd6b0"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Gas6 derived from cancer-associated fibroblasts promotes migration of Axl-expressing lung cancer cells during chemotherapy", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Gas6 derived from cancer-associated fibroblasts promotes migration of Axl-expressing lung cancer cells during chemotherapy"}]}, "item_type_id": "4", "owner": "18", "path": ["1134"], "permalink_uri": "https://doi.org/10.24517/00062988", "pubdate": {"attribute_name": "公開日", "attribute_value": "2021-07-05"}, "publish_date": "2021-07-05", "publish_status": "0", "recid": "56714", "relation": {}, "relation_version_is_last": true, "title": ["Gas6 derived from cancer-associated fibroblasts promotes migration of Axl-expressing lung cancer cells during chemotherapy"], "weko_shared_id": -1}
Gas6 derived from cancer-associated fibroblasts promotes migration of Axl-expressing lung cancer cells during chemotherapy
https://doi.org/10.24517/00062988
https://doi.org/10.24517/000629881d4b103c-a735-430d-975a-3dfe6235d85e
名前 / ファイル | ライセンス | アクション |
---|---|---|
ME-PR-NAITO-H-10613.pdf (4.2 MB)
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2021-07-05 | |||||
タイトル | ||||||
タイトル | Gas6 derived from cancer-associated fibroblasts promotes migration of Axl-expressing lung cancer cells during chemotherapy | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.24517/00062988 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Ryu Kanzaki,
× Ryu Kanzaki,× Naito, Hisamichi× Kise, Kazuyoshi× Takara, Kazuhiro× Eino, Daisuke× Minami, Masato× Shintani, Yasushi× Funaki, Soichiro× Kawamura, Tomohiro× Kimura, Toru× Okumura, Meinoshin× Takakura, Nobuyuki |
|||||
著者別表示 |
内藤, 尚道
× 内藤, 尚道× 高倉, 伸幸 |
|||||
提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医薬保健研究域医学系 | |||||
書誌情報 |
Scientific Reports 巻 7, 号 1, p. 10613, 発行日 2017-09-06 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2045-2322 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1038/s41598-017-10873-2 | |||||
出版者 | ||||||
出版者 | Nature Research / Nature Publishing Group | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Alterations to the tumor stromal microenvironment induced by chemotherapy could influence the behavior of cancer cells. In the tumor stromal microenvironment, cancer-associated fibroblasts (CAFs) play an important role. Because the receptor tyrosine kinase Axl and its ligand Gas6 could be involved in promoting non-small cell lung cancer (NSCLC), we investigated the role of Gas6 secreted by CAFs during chemotherapy in NSCLC. In a murine model, we found that Gas6 expression by CAFs was upregulated following cisplatin treatment. Gas6 expression might be influenced by intratumoral hypoperfusion during chemotherapy, and it increased after serum starvation in a human lung CAF line, LCAFhTERT. Gas6 is associated with LCAFhTERT cell growth. Recombinant Gas6 promoted H1299 migration, and conditioned medium (CM) from LCAFhTERT cells activated Axl in H1299 cells and promoted migration. Silencing Gas6 in LCAFhTERT reduced the Axl activation and H1299 cell migration induced by CM from LCAFhTERT. In clinical samples, stromal Gas6 expression increased after chemotherapy. Five-year disease-free survival rates for patients with tumor Axl- and stromal Gas6-positive tumors (n = 37) was significantly worse than for the double negative group (n = 12) (21.9% vs 51.3%, p = 0.04). Based on these findings, it is presumed that Gas6 derived from CAFs promotes migration of Axl-expressing lung cancer cells during chemotherapy and is involved in poor clinical outcome. © 2017 The Author(s). | |||||
権利 | ||||||
権利情報 | copyright © Nature Research | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.nature.com/srep/index.html | |||||
関連名称 | http://www.nature.com/srep/index.html | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.nature.com/articles/s41598-017-10873-2 | |||||
関連名称 | https://www.nature.com/articles/s41598-017-10873-2 |