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Radiotheranostics coupled between an At-211-Labeled RGD peptide and the corresponding radioiodine-labeled RGD peptide
https://doi.org/10.24517/00065250
https://doi.org/10.24517/00065250625f593a-ba68-4957-95c8-84b608ebf2a2
名前 / ファイル | ライセンス | アクション |
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ME-PR-SHIBA-K-2019-4-4584.pdf (851.9 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-01-28 | |||||
タイトル | ||||||
タイトル | Radiotheranostics coupled between an At-211-Labeled RGD peptide and the corresponding radioiodine-labeled RGD peptide | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.24517/00065250 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Ogawa, Kazuma
× Ogawa, Kazuma× Takeda, Takuya× Mishiro, Kenji× Toyoshima, Atsushi× Shiba, Kazuhiro× Yoshimura, Takashi× Shinohara, Atsushi× Kinuya, Seigo× Odani, Akira |
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著者別表示 |
小川, 数馬
× 小川, 数馬× 三代, 憲司× 柴, 和弘× 絹谷, 清剛× 小谷, 明 |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学疾患モデル総合研究センター | |||||
書誌情報 |
ACS Omega 巻 4, 号 3, p. 4584-4591, 発行日 2019 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2470-1343 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1021/acsomega.8b03679 | |||||
出版者 | ||||||
出版者 | American Chemical Society | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Alpha particle-emitting radionuclides have gained considerable attention for radionuclide therapy. Astatine-211 ( 211 At) is a promising alpha particle-emitting radionuclide. 211 At is a halogen that has similar chemical properties to iodine and exhibits a half-life of 7.2 h. However, direct labeling of proteins or peptides into the tyrosine residue with 211 At was shown to be impractical. Herein, we demonstrate a novel 211 At-labeling method using the RGD peptide as a model peptide. An 211 At-labeled RGD peptide, [ 211 At]c[RGDf(4-At)K], was prepared from a precursor with a tributylstannyl group on the phenylalanine residue in c(RGDfK) with a radiochemical yield of 63% and a radiochemical purity of >96%, and its potential for targeted radionuclide therapy was evaluated. Based on the results of biodistribution experiments, [ 125 I]c[RGDf(4-I)K] and [ 211 At]c[RGDf(4-At)K] showed high accumulation in the tumor and similar biodistribution. This study provides useful information for radiotheranostics between an 211 At-labeled peptide and the corresponding radioiodine-labeled peptide. © 2019 American Chemical Society. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes. | |||||
権利 | ||||||
権利情報 | Copyright © American Chemical Society | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://pubs.acs.org/journal/acsodf | |||||
関連名称 | http://pubs.acs.org/journal/acsodf |