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膵自家異所移植の研究
https://doi.org/10.24517/00068032
https://doi.org/10.24517/00068032590ce3b3-c490-4c45-becc-d762863da663
名前 / ファイル | ライセンス | アクション |
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ME-PR-MIWA-K-kaken 1988-2p.pdf (90.0 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2022-11-07 | |||||
タイトル | ||||||
タイトル | 膵自家異所移植の研究 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Heterotopic autotransplantation of segmental pancreas | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00068032 | |||||
ID登録タイプ | JaLC | |||||
著者別表示 |
Miwa, Koichi
× Miwa, Koichi |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大医学部 | |||||
書誌情報 |
昭和61(1986)年度 科学研究費補助金 一般研究(C) 研究成果報告書概要 en : 1986 Fiscal Year Final Research Report Summary 巻 1985 – 1986, p. 2p., 発行日 1988-11-08 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 異所移植された自家膵の機能と形態の変化を臨床的・実験的に検索した。第1例は62才の男性で膵頭部癌で膵全摘を行い、尾側膵を脾動静脈と大腿動静脈分枝の血管吻合で大腿皮下に移植した。移植膵量は全膵重量の約50%で、組織学的に正常膵であった。移植後の糖代謝は、正常に維持され、術後6週目のIV-GTTの血糖値は術前と同じ正常パターンを示した。しかし、IRIの初期分泌反応は欠如していた。また外瘻より分泌される膵液は1日100-400ml,アミレース値は20-80×【10^4】I.U.で、5か月後まで機能低下はみられなかった。6ケ月後の剖検時の移植膵は、葉間や葉内に線維増生がみられ、腺房細胞は減少し、中等度の萎縮がみられた。ラ島は細胞数が増し、過形成を示し、インシュリン抗体を用いたPAP法によるB細胞の染色性は良好であった。他の1例は50歳の男性で、開腹したが切除不能で、併存する糖尿の改善を意図して尾側膵約30%を大腿皮下に血管吻合で異所移植した。移植膵は、強度の線維化・腺房細胞の萎縮をみる慢性膵炎像を示していたがラ島は良く保持されていた。術前30-92g/day排泄されていた尿糖は、術後2週間で0-10gと減少し、3週以降は陰性となった。しかし、IV-GTTによる血糖曲線は改善されなかった。膵液分泌量は1日3-13mlであった。6カ月後の死亡時の膵臓は、ラ島が良く保存され、B細胞の良好な染色性が観察された。犬を用いた実験では、膵右葉切除後に、膵左葉を脾動静脈を血管系として腸骨血管に異所移植した犬では、膵右葉切除のみの対照に比べて、糖刺激による末梢静脈血インシュリン値は、高値を示す傾向にあった。膵自家異所移植にさいして、膵臓への自律神経遮断が末梢静脈血のインシュリン高値に影響を与えているか否かは未解決の問題として残った。以上の臨床的・実験的観察より、異所移植された膵臓は、非移植の対照に比べ、糖代謝により有利に働いているようである。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The aim of the present study was to evaluate the function and morphological change of heterotopic autotransolanted pancreas which was denervated and secreted its hormons into the systemic circulation instead of the portal system. A 62 years old patient had undergone total pancreatectomy for pancreas cancer and autotransplantation of the distal half of pancreas by anastomosis of the splenic vessels to the branches of femoral vessels. The autotransplanted pancreas was normal in histology. Postoperatively, his carbohydrate metabolism was maintained normally and IV-GTT test showed normal blood glucose levels as well as that done preoperatively, though IRI response was impaired with abscence of an early secretory peak. Also the pancreatic exocrine secretion from the external fistula did not decrease in volume and in amylase concentration. However, when he died at the 6th postoperative month, the pancreas consisted of inter- and intra-lobular fibrosis, acinar atrophy, and hypertrophic islets. Another patient, 50 years old man with unresectable pancreatic cancer, excreted a 30-92g of urine sugar daily. In order to improve his impaired carbohydrate metabolism, the distal a third of pancreas with severe chronic pancreatitis was resected and autotransplanted at his thigh. Following the operation, his daily urinary glucose output decreased to 0-10g during the first post-operative two weeks and then disappeared. However, IV-GTT was not improved. Experimental studies demonstrated that peripheral insulin levels after glucose load in the dogs which received heterotopic autotransplantaion of the left limb of pancreas following total pancretectomy were higher, though not significantly in statistics, than those in the control in which the right limb of pancreas was removed. However, it remains to be unresolved whether denervation may be responsible for the higher level of peripheral insulin in the animals with autotransplanted pancreas. Based on these observations, it is concluded that heterotopic autotranasplanted pancreas may offer some advantage in the carbohydrate control over the non-transplanted one. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:60570621, 研究期間(年度):1985 – 1986 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:研究課題「膵自家異所移植の研究」課題番号60570621 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-60570621/605706211986kenkyu_seika_hokoku_gaiyo/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=80019968 | |||||
関連名称 | https://kaken.nii.ac.jp/search/?qm=80019968 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-60570621/ | |||||
関連名称 | https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-60570621/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-60570621/605706211986kenkyu_seika_hokoku_gaiyo/ | |||||
関連名称 | https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-60570621/605706211986kenkyu_seika_hokoku_gaiyo/ |