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Increased Circulating Matrix Metalloproteinase-2 in Patients with Hypertrophic Cardiomyopathy with Systolic Dysfunction
http://hdl.handle.net/2297/7196
http://hdl.handle.net/2297/71962e73cbde-eb9f-4ced-b523-39079a8c5cf0
名前 / ファイル | ライセンス | アクション |
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ME-PR-MABUCHI-H-P355.pdf (246.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-03 | |||||
タイトル | ||||||
タイトル | Increased Circulating Matrix Metalloproteinase-2 in Patients with Hypertrophic Cardiomyopathy with Systolic Dysfunction | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Noji, Yoshihiro
× Noji, Yoshihiro× Shimizu, Masami× Ino, Hidekazu× Higashikata, Toshinori× Yamaguchi, Masato× Nohara, Atsushi× Horita, Takahiro× Shimizu, Kuniyoshi× Ito, Yuji× Matsuda, Takeshi× Namura, Masanobu× Mabuchi, Hiroshi |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学大学院医学系研究科 | |||||
書誌情報 |
Circulation Journal 巻 68, 号 4, p. 355-360, 発行日 2004-04-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1346-9843 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11591968 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1253/circj.68.355 | |||||
政府刊行物番号 | ||||||
内容記述タイプ | Other | |||||
内容記述 | http://www.jstage.jst.go.jp/article/circj/68/4/68_355/_article | |||||
出版者 | ||||||
出版者 | 日本循環器学会 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background: Some patients with hypertrophic cardiomyopathy (HCM) develop left ventricular (LV) wall thinning associated with LV dilatation and systolic dysfunction. Recently, matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPS) were reported to be involved in ventricular remodeling, however, little is known about MMPs and TIMPs in patients with HCM. Methods and Results: Enzyme-linked immunoassays were used to measure the plasma concentrations of MMP-2, MMP-3, MMP-9, TIMP-1, and TIMP-2 in 11 patients with HCM accompanied by systolic dysfunction (fractional shortening (FS) <25%, group A), 17 patients with HCM who had preserved systolic function (FS ≥25%, group B), and 50 age-matched clinically healthy control subjects (mean age: 57 years). The concentration of MMP-2 in group A was significantly higher than in group B and the control subjects (1,124±84, 792±49, 809+26 ng/ml, respectively), whereas there was no significant difference between group B and the control subjects. MMP-2 concentrations significantly increased as the New York Heart Association functional class increased in patients with HCM. TIMP-2 was also significantly higher in group A patients than in group B and the control subjects (45.3±4.7, 34.6±2.2, 33.7±1.8 ng/ml, respectively), but there was no difference between group B and control subjects. TIMP-1 was significantly higher in HCM patients than in control subjects. MMP-3 and MMP-9 concentrations did not differ among the 3 groups. Both MMP-2 and TIMP-2 correlated significantly with FS and LV dimension, negatively and positively, respectively. Conclusions: These results suggest that changes in the release and activity of MMP-2 and TIMP-2 may be associated with the mechanisms responsible for cardiac remodeling in patients with HCM. | |||||
権利 | ||||||
権利情報 | 日本循環器学会の許諾を得て登録 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |