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  1. C. 医薬保健学域; 医学類・薬学類・医薬科学類・保健学類
  2. c 10. 学術雑誌掲載論文(医・保健)
  3. 1. 査読済論文(医学・保健)

Increased Circulating Matrix Metalloproteinase-2 in Patients with Hypertrophic Cardiomyopathy with Systolic Dysfunction

http://hdl.handle.net/2297/7196
http://hdl.handle.net/2297/7196
2e73cbde-eb9f-4ced-b523-39079a8c5cf0
名前 / ファイル ライセンス アクション
ME-PR-MABUCHI-H-P355.pdf ME-PR-MABUCHI-H-P355.pdf (246.6 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-10-03
タイトル
タイトル Increased Circulating Matrix Metalloproteinase-2 in Patients with Hypertrophic Cardiomyopathy with Systolic Dysfunction
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 Noji, Yoshihiro

× Noji, Yoshihiro

WEKO 21160

Noji, Yoshihiro

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Shimizu, Masami

× Shimizu, Masami

WEKO 21161

Shimizu, Masami

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Ino, Hidekazu

× Ino, Hidekazu

WEKO 21162

Ino, Hidekazu

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Higashikata, Toshinori

× Higashikata, Toshinori

WEKO 21163

Higashikata, Toshinori

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Yamaguchi, Masato

× Yamaguchi, Masato

WEKO 20099
e-Rad 90313650
研究者番号 90313650

Yamaguchi, Masato

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Nohara, Atsushi

× Nohara, Atsushi

WEKO 342
e-Rad 50313648
金沢大学研究者情報 50313648
研究者番号 50313648

Nohara, Atsushi

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Horita, Takahiro

× Horita, Takahiro

WEKO 21164

Horita, Takahiro

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Shimizu, Kuniyoshi

× Shimizu, Kuniyoshi

WEKO 21165

Shimizu, Kuniyoshi

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Ito, Yuji

× Ito, Yuji

WEKO 21166

Ito, Yuji

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Matsuda, Takeshi

× Matsuda, Takeshi

WEKO 21167

Matsuda, Takeshi

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Namura, Masanobu

× Namura, Masanobu

WEKO 21168

Namura, Masanobu

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Mabuchi, Hiroshi

× Mabuchi, Hiroshi

WEKO 389
e-Rad 00019960
研究者番号 00019960

Mabuchi, Hiroshi

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提供者所属
内容記述タイプ Other
内容記述 金沢大学大学院医学系研究科
書誌情報 Circulation Journal

巻 68, 号 4, p. 355-360, 発行日 2004-04-01
ISSN
収録物識別子タイプ ISSN
収録物識別子 1346-9843
NCID
収録物識別子タイプ NCID
収録物識別子 AA11591968
DOI
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 https://doi.org/10.1253/circj.68.355
政府刊行物番号
内容記述タイプ Other
内容記述 http://www.jstage.jst.go.jp/article/circj/68/4/68_355/_article
出版者
出版者 日本循環器学会
抄録
内容記述タイプ Abstract
内容記述 Background: Some patients with hypertrophic cardiomyopathy (HCM) develop left ventricular (LV) wall thinning associated with LV dilatation and systolic dysfunction. Recently, matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPS) were reported to be involved in ventricular remodeling, however, little is known about MMPs and TIMPs in patients with HCM. Methods and Results: Enzyme-linked immunoassays were used to measure the plasma concentrations of MMP-2, MMP-3, MMP-9, TIMP-1, and TIMP-2 in 11 patients with HCM accompanied by systolic dysfunction (fractional shortening (FS) <25%, group A), 17 patients with HCM who had preserved systolic function (FS ≥25%, group B), and 50 age-matched clinically healthy control subjects (mean age: 57 years). The concentration of MMP-2 in group A was significantly higher than in group B and the control subjects (1,124±84, 792±49, 809+26 ng/ml, respectively), whereas there was no significant difference between group B and the control subjects. MMP-2 concentrations significantly increased as the New York Heart Association functional class increased in patients with HCM. TIMP-2 was also significantly higher in group A patients than in group B and the control subjects (45.3±4.7, 34.6±2.2, 33.7±1.8 ng/ml, respectively), but there was no difference between group B and control subjects. TIMP-1 was significantly higher in HCM patients than in control subjects. MMP-3 and MMP-9 concentrations did not differ among the 3 groups. Both MMP-2 and TIMP-2 correlated significantly with FS and LV dimension, negatively and positively, respectively. Conclusions: These results suggest that changes in the release and activity of MMP-2 and TIMP-2 may be associated with the mechanisms responsible for cardiac remodeling in patients with HCM.
権利
権利情報 日本循環器学会の許諾を得て登録
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
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