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Critical role of JSAP1 and JLP in axonal transport in the cerebellar Purkinje cells of mice
http://hdl.handle.net/2297/43409
http://hdl.handle.net/2297/43409a27769bf-31d6-44b6-a3e8-998fd8cac8da
名前 / ファイル | ライセンス | アクション |
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CA-PR-YOSHIOKA-K-2805.pdf (1.4 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-05 | |||||
タイトル | ||||||
タイトル | Critical role of JSAP1 and JLP in axonal transport in the cerebellar Purkinje cells of mice | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Sato, Tokiharu
× Sato, Tokiharu× Ishikawa, Momoe× Yoshihara, Toru× Nakazato, Ryota× Higashida, Haruhiro× Asano, Masahide× Yoshioka, Katsuji |
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書誌情報 |
FEBS Letters 巻 589, 号 19, p. 2805-2811, 発行日 2015-07-03 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0014-5793 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00642943 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.febslet.2015.08.024 | |||||
出版者 | ||||||
出版者 | Elsevier B. V. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | JNK/stress-activated protein kinase-associated protein 1 (JSAP1) and JNK-associated leucine zipper protein (JLP) are structurally related scaffolding proteins that are highly expressed in the brain. Here, we found that JSAP1 and JLP play functionally redundant and essential roles in mouse cerebellar Purkinje cell (PC) survival. Mice containing PCs with deletions in both JSAP1 and JLP exhibited PC axonal dystrophy, followed by gradual, progressive neuronal loss. Kinesin-1 cargoes accumulated selectively in the swollen axons of Jsap1/Jlp-deficient PCs. In addition, autophagy inactivation in these mice markedly accelerated PC degeneration. These findings suggest that JSAP1 and JLP play critical roles in kinesin-1-dependent axonal transport, which prevents brain neuronal degeneration. © 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Embargo Period (12 mouths) | |||||
権利 | ||||||
権利情報 | Copyright © Elsevier (CC-BY NC ND) | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.elsevier.com/locate/issn/00145793 |