WEKO3
インデックスリンク
アイテム
{"_buckets": {"deposit": "0ab7149f-ee34-458a-87fc-8757364258e5"}, "_deposit": {"created_by": 3, "id": "30994", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "30994"}, "status": "published"}, "_oai": {"id": "oai:kanazawa-u.repo.nii.ac.jp:00030994", "sets": ["2231"]}, "author_link": ["69"], "item_11_biblio_info_8": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2011-01-01", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "207", "bibliographicPageStart": "185", "bibliographic_titles": [{"bibliographic_title": "The Sciatic Nerve: Blocks, Injuries and Regeneration"}]}]}, "item_11_description_21": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Inflammatory cytokines play important roles in a variety of pathophysiological changes associated with traumatic injury and demyelinating disorders in the peripheral nervous system. After sciatic nerve injury, proinflammatory cytokines such as interleukin 1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNFα) are produced by and act on neurons, Schwann cells, and infiltrating inflammatory cells at the lesion site. Underlying these processes is receptor-mediated activation of intracellular signaling pathways that regulate cell differentiation and proliferation and synthesis of axon and myelin components. This review focuses on roles of inflammatory cytokines in the degeneration and regeneration of the peripheral nerve. In addition, we describe here altered expression of inflammatory cytokines in gradually elongated rat sciatic nerves. This experimental model, which is devoid of Wallerian degeneration, provides insights into the involvement of inflammatory cytokines in the maintenance of myelinated axons. Based on the findings obtained from nerve elongation models and those from conventional nerve injury models, we discuss the molecular mechanism that ensures the integrity of the peripheral nerve. © 2011 by Nova Science Publishers, Inc. All rights reserved.", "subitem_description_type": "Abstract"}]}, "item_11_publisher_17": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Nova Science Publishers"}]}, "item_11_relation_10": {"attribute_name": "ISBN", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "978-161122916-5", "subitem_relation_type_select": "ISBN"}}]}, "item_11_rights_23": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2011 by Nova Science Publishers, Inc."}]}, "item_11_version_type_25": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Yokoyama, Shigeru"}], "nameIdentifiers": [{"nameIdentifier": "69", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "00210633", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=00210633"}, {"nameIdentifier": "00210633", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=00210633"}, {"nameIdentifier": "00210633", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000000210633"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-10-05"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "ME-PR-YOKOYAMA-S-185.pdf", "filesize": [{"value": "426.8 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 426800.0, "url": {"label": "ME-PR-YOKOYAMA-S-185.pdf", "url": "https://kanazawa-u.repo.nii.ac.jp/record/30994/files/ME-PR-YOKOYAMA-S-185.pdf"}, "version_id": "4ff17b34-23d1-4f57-8057-addedbbb5d3a"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "book", "resourceuri": "http://purl.org/coar/resource_type/c_2f33"}]}, "item_title": "Inflammatory cytokines in degeneration, regeneration and maintenance of sciatic nerve", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Inflammatory cytokines in degeneration, regeneration and maintenance of sciatic nerve"}]}, "item_type_id": "11", "owner": "3", "path": ["2231"], "permalink_uri": "http://hdl.handle.net/2297/37022", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-10-05"}, "publish_date": "2017-10-05", "publish_status": "0", "recid": "30994", "relation": {}, "relation_version_is_last": true, "title": ["Inflammatory cytokines in degeneration, regeneration and maintenance of sciatic nerve"], "weko_shared_id": -1}
Inflammatory cytokines in degeneration, regeneration and maintenance of sciatic nerve
http://hdl.handle.net/2297/37022
http://hdl.handle.net/2297/37022e86e9768-a863-4b81-9f62-1f2fa7db1ffb
名前 / ファイル | ライセンス | アクション |
---|---|---|
ME-PR-YOKOYAMA-S-185.pdf (426.8 kB)
|
|
Item type | 図書 / Book(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2017-10-05 | |||||
タイトル | ||||||
タイトル | Inflammatory cytokines in degeneration, regeneration and maintenance of sciatic nerve | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_2f33 | |||||
資源タイプ | book | |||||
著者 |
Yokoyama, Shigeru
× Yokoyama, Shigeru |
|||||
書誌情報 |
The Sciatic Nerve: Blocks, Injuries and Regeneration p. 185-207, 発行日 2011-01-01 |
|||||
ISBN | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | ISBN | |||||
関連識別子 | 978-161122916-5 | |||||
出版者 | ||||||
出版者 | Nova Science Publishers | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Inflammatory cytokines play important roles in a variety of pathophysiological changes associated with traumatic injury and demyelinating disorders in the peripheral nervous system. After sciatic nerve injury, proinflammatory cytokines such as interleukin 1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNFα) are produced by and act on neurons, Schwann cells, and infiltrating inflammatory cells at the lesion site. Underlying these processes is receptor-mediated activation of intracellular signaling pathways that regulate cell differentiation and proliferation and synthesis of axon and myelin components. This review focuses on roles of inflammatory cytokines in the degeneration and regeneration of the peripheral nerve. In addition, we describe here altered expression of inflammatory cytokines in gradually elongated rat sciatic nerves. This experimental model, which is devoid of Wallerian degeneration, provides insights into the involvement of inflammatory cytokines in the maintenance of myelinated axons. Based on the findings obtained from nerve elongation models and those from conventional nerve injury models, we discuss the molecular mechanism that ensures the integrity of the peripheral nerve. © 2011 by Nova Science Publishers, Inc. All rights reserved. | |||||
権利 | ||||||
権利情報 | © 2011 by Nova Science Publishers, Inc. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa |