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Temozolomide combined with irinotecan regresses a cisplatinumresistant relapsed osteosarcoma in a patient-derived orthotopic xenograft (PDOX) precision-oncology mouse model
https://doi.org/10.24517/00050489
https://doi.org/10.24517/000504891bade475-ec30-45bc-9c30-d6a49e45ade7
名前 / ファイル | ライセンス | アクション |
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ME-PR-IGARASHI-K-7774.pdf (2.5 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-04-13 | |||||
タイトル | ||||||
タイトル | Temozolomide combined with irinotecan regresses a cisplatinumresistant relapsed osteosarcoma in a patient-derived orthotopic xenograft (PDOX) precision-oncology mouse model | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.24517/00050489 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Igarashi, Kentaro
× Igarashi, Kentaro× Kawaguchi, Kei× Kiyuna, Tasuku× Miyake, Kentaro× Miyake, Masuyo× Li, Yunfeng× Nelson, Scott D.× Dry, Sarah M.× Singh, Arun S.× Elliott, Irmina A.× Russell, Tara A.× Eckardt, Mark A.× Yamamoto, Norio× Hayashi, Katsuhiro× Kimura, Hiroaki× Miwa, Shinji× Tsuchiya, Hiroyuki× Eilber, Fritz C.× Hoffman, Robert M. |
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著者別表示 |
五十嵐, 健太郎
× 五十嵐, 健太郎× 山本, 憲男× 林, 克洋× 三輪, 真嗣× 土屋, 弘行 |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医薬保健研究域医学系 | |||||
書誌情報 |
Oncotarget 巻 9, 号 8, p. 7774-7781, 発行日 2018 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1949-2553 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.18632/oncotarget.22892 | |||||
出版者 | ||||||
出版者 | Impact Journals LLC | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Relapsed osteosarcoma is a recalcitrant tumor. A patient's cisplatinum (CDDP)- resistant relapsed osteosarcoma lung metastasis was previously established orthotopically in the distal femur of mice to establish a patient-derived orthotopic xenograft (PDOX) model. In the present study, the PDOX models were randomized into the following groups when tumor volume reached 100 mm3: G1, control without treatment; G2, CDDP (6 mg/kg, intraperitoneal (i.p.) injection, weekly, for 2 weeks); gemcitabine (GEM) (100 mg/kg, i.p., weekly, for 2 weeks) combined with docetaxel (DOC) (20 mg/kg, i.p., once); temozolomide (TEM) (25 mg/kg, p.o., daily, for 2 weeks) combined with irinotecan (IRN) (4 mg/kg i.p., daily for 2 weeks). Tumor size and body weight were measured with calipers and a digital balance twice a week. After 2 weeks, all treatments significantly inhibited tumor growth except CDDP compared to the untreated control: CDDP: p = 0.093; GEM+DOC: p = 0.0002, TEM+IRN: p < 0.0001. TEM combined with IRN was significantly more effective than either CDDP (p = 0.0001) or GEM combined with DOC (p = 0.0003) and significantly regressed the tumor volume compared to day 0 (p = 0.003). Thus the PDOX model precisely identified the combination of TEM-IRN that could regress the CDDP-resistant relapsed metastatic osteosarcoma PDOX. © Igarashi et al. | |||||
権利 | ||||||
権利情報 | Copyright © Igarashi et al. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |