We performed immunohistochemical analysis and found that JSAP1, a scaffold protein for JNK signaling pathways, is expressed predominantly in the post-mitotic granule cell precursors (GCPs) of the inner external granular layer. We also showed that when stimulated by FGF receptor, JSAP1 translocates to the plasma membrane, where it recruits JNK and facilitates the activation of JNK, leading to the differentiation of cerebellar GCPs. Furthermore, we found that JSAP1-JNK signaling promotes the cell cycle exit and differentiation of cerebellar GCPs.
足場タンパク質JSAP1による小脳顆粒前駆細胞の増殖・分化制御機構の解析
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CA-PR-YOSHIOKA-K-kaken 2011-5p.pdf
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