Development of prophylactic method and clarification of mechanism for anti-tumor drug-induced vascular pain by using approach both basic and clinical syudies
ゲムシタビン塩酸塩（GEM）やオキサリプラチン（L-OHP）を末梢静脈から投与した際に生じる血管痛は，がん薬物療法を行う上での大きな問題点となっている．血管痛を予防・軽減をするためには，血管痛の発現機序を明らかにしたうえで，予防対策を考案する必要がある．そこで，本申請課題では，基礎研究・臨床研究を統合し，発痛機序および予防対策について検討した．その結果，血管痛は投与する抗がん剤の投与量に依存することから，単位時間当たりの投与量を少なくする（投与時間を延長する）ことで予防できることが示唆された．また，血管痛を起こす薬剤により，発痛機序が異なる可能性が示された．
Vascular pain induced by administration of gemcitabine (GEM) or oxaliplatin (L-OHP) via peripheral venous is major problem in patients received cancer chemotherapy. To elucidate the mechanism of vascular pain will be required before prophylactic methods are established in clinical setting. The purpose of this study was to develop a useful prophylactic method for vascular pain in clinical setting and to clarify the inciting factor of pain that occur around the injection site or peripheral vein by using approach both basic and clinical studies. The results in this study suggested that vascular pain is depend on the dosage per unit of time, resulting from that extending the administration time of GEM or L-OHP could reduce the intensity of vascular pain and the mechanism of vascular pain could differ from agents associated with this pain.
抗癌剤による血管痛の誘発要因および予防策の基礎・臨床統合的検証
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PH-PR-SUGA-Y-kaken 2016-4p.pdf
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