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Targeting inflammatory cytokines-androgen receptor (AR) signaling with ASC-J9® to better battle prostate cancer progression
http://hdl.handle.net/2297/37576
http://hdl.handle.net/2297/37576534ef81a-85f7-43a0-9ada-fadafcfa97b0
名前 / ファイル | ライセンス | アクション |
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ME-PR-IZUMI-K-1-3.pdf (429.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-03 | |||||
タイトル | ||||||
タイトル | Targeting inflammatory cytokines-androgen receptor (AR) signaling with ASC-J9® to better battle prostate cancer progression | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Izumi, Kouji
× Izumi, Kouji× Chang, Chawnshang |
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書誌情報 |
OncoImmunology 巻 2, 号 12, p. 1-3, 発行日 2013-10-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2162-4011 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.4161/onci.26853 | |||||
出版者 | ||||||
出版者 | Landes Bioscience | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Inflammatory cytokines and chemokines released by macrophages in the prostate cancer microenvironment may signal via the androgen receptor (AR ) to influence tumor progression. In particular, macrophages appear to promote tumorigenesis by altering the chemokine (C-C motif) ligand 4 (CCL4)/AR signaling axis. This process can be blocked by AS C-J9®, an enhancer of AR degradation. AS C-J9® also inhibits the CCL2-dependent, signal transducer and activator of transcription 3 (STAT3)-mediated pro-metastatic signaling cascade that is generally activated by androgen deprivation therapy. Thus, targeting inflammatory cytokines signaling via the AR , with AS C-J9®, represents a promising therapeutic approach against prostate cancer progression. © 2013 Landes Bioscience. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa |