WEKO3
インデックスリンク
アイテム
{"_buckets": {"deposit": "13c6242a-87c8-410d-9d4c-691cb8e28305"}, "_deposit": {"created_by": 18, "id": "43193", "owners": [18], "pid": {"revision_id": 0, "type": "depid", "value": "43193"}, "status": "published"}, "_oai": {"id": "oai:kanazawa-u.repo.nii.ac.jp:00043193", "sets": ["1134"]}, "author_link": ["73427", "73429", "69598", "73428", "73426", "69597"], "item_4_biblio_info_8": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2017-12-01", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "7", "bibliographicPageStart": "1", "bibliographicVolumeNumber": "635", "bibliographic_titles": [{"bibliographic_title": "Archives of Biochemistry and Biophysics"}]}]}, "item_4_creator_33": {"attribute_name": "著者別表示", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "櫻井, 博"}], "nameIdentifiers": [{"nameIdentifier": "69598", "nameIdentifierScheme": "WEKO"}]}]}, "item_4_description_21": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Growth arrest and DNA damage-inducible 45 (GADD45) family genes encode related proteins, including GADD45α, GADD45β, and GADD45γ. In HeLa cells, expression of GADD45 members is differentially regulated under a variety of environmental conditions, but thermal and genotoxic stresses induce the expression of all genes. The heat shock response of GADD45β is mediated by the heat shock transcription factor 1 (HSF1), and GADD45β is necessary for heat stress survival. Heat and genotoxic stress-induced activation of c-Jun N-terminal kinase (JNK) is suppressed by the expression of GADD45 proteins. GADD45 proteins bind the JNK kinase mitogen-activated protein kinase kinase 7 (MKK7) and inhibit its activity, even under normal physiological conditions. Our findings indicate that GADD45 essentially suppresses the MKK7-JNK pathway and suggest that differentially expressed GADD45 family members fine-tune stress-inducible JNK activity. © 2017 Elsevier Inc.", "subitem_description_type": "Abstract"}]}, "item_4_description_22": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "Embargo Period 12 months", "subitem_description_type": "Other"}]}, "item_4_description_5": {"attribute_name": "提供者所属", "attribute_value_mlt": [{"subitem_description": "金沢大学医薬保健研究域保健学系 ", "subitem_description_type": "Other"}]}, "item_4_identifier_registration": {"attribute_name": "ID登録", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.24517/00049540", "subitem_identifier_reg_type": "JaLC"}]}, "item_4_publisher_17": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Academic Press Inc."}]}, "item_4_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1016/j.abb.2017.10.005", "subitem_relation_type_select": "DOI"}}]}, "item_4_rights_23": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Copyright © 2017 Elsevier Inc.(CC-BY NC ND) "}, {"subitem_rights": "http://www.elsevier.com/locate/issn/00039861"}]}, "item_4_source_id_11": {"attribute_name": "NCID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00547159", "subitem_source_identifier_type": "NCID"}]}, "item_4_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0003-9861", "subitem_source_identifier_type": "ISSN"}]}, "item_4_version_type_25": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Ueda, Takumi"}], "nameIdentifiers": [{"nameIdentifier": "73426", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kohama, Yuri"}], "nameIdentifiers": [{"nameIdentifier": "73427", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kuge, Ayana"}], "nameIdentifiers": [{"nameIdentifier": "73428", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kido, Eriko"}], "nameIdentifiers": [{"nameIdentifier": "73429", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sakurai, Hiroshi"}], "nameIdentifiers": [{"nameIdentifier": "69597", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "00225848", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=00225848"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-12-02"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "ME-PR-SAKURAI-H-1.pdf", "filesize": [{"value": "2.6 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_6", "mimetype": "application/pdf", "size": 2600000.0, "url": {"label": "ME-PR-SAKURAI-H-1.pdf", "url": "https://kanazawa-u.repo.nii.ac.jp/record/43193/files/ME-PR-SAKURAI-H-1.pdf"}, "version_id": "518925af-4520-4374-87c9-391690b4c527"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "GADD45", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Heat shock", "subitem_subject_scheme": "Other"}, {"subitem_subject": "HSF1", "subitem_subject_scheme": "Other"}, {"subitem_subject": "JNK", "subitem_subject_scheme": "Other"}, {"subitem_subject": "MKK7", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "GADD45 family proteins suppress JNK signaling by targeting MKK7", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "GADD45 family proteins suppress JNK signaling by targeting MKK7"}]}, "item_type_id": "4", "owner": "18", "path": ["1134"], "permalink_uri": "https://doi.org/10.24517/00049540", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-12-22"}, "publish_date": "2017-12-22", "publish_status": "0", "recid": "43193", "relation": {}, "relation_version_is_last": true, "title": ["GADD45 family proteins suppress JNK signaling by targeting MKK7"], "weko_shared_id": -1}
GADD45 family proteins suppress JNK signaling by targeting MKK7
https://doi.org/10.24517/00049540
https://doi.org/10.24517/0004954069516ddf-27bb-4735-9e85-e9c62da6d1ef
名前 / ファイル | ライセンス | アクション |
---|---|---|
ME-PR-SAKURAI-H-1.pdf (2.6 MB)
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2017-12-22 | |||||
タイトル | ||||||
タイトル | GADD45 family proteins suppress JNK signaling by targeting MKK7 | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.24517/00049540 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Ueda, Takumi
× Ueda, Takumi× Kohama, Yuri× Kuge, Ayana× Kido, Eriko× Sakurai, Hiroshi |
|||||
著者別表示 |
櫻井, 博
× 櫻井, 博 |
|||||
提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医薬保健研究域保健学系 | |||||
書誌情報 |
Archives of Biochemistry and Biophysics 巻 635, p. 1-7, 発行日 2017-12-01 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0003-9861 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00547159 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.abb.2017.10.005 | |||||
出版者 | ||||||
出版者 | Academic Press Inc. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Growth arrest and DNA damage-inducible 45 (GADD45) family genes encode related proteins, including GADD45α, GADD45β, and GADD45γ. In HeLa cells, expression of GADD45 members is differentially regulated under a variety of environmental conditions, but thermal and genotoxic stresses induce the expression of all genes. The heat shock response of GADD45β is mediated by the heat shock transcription factor 1 (HSF1), and GADD45β is necessary for heat stress survival. Heat and genotoxic stress-induced activation of c-Jun N-terminal kinase (JNK) is suppressed by the expression of GADD45 proteins. GADD45 proteins bind the JNK kinase mitogen-activated protein kinase kinase 7 (MKK7) and inhibit its activity, even under normal physiological conditions. Our findings indicate that GADD45 essentially suppresses the MKK7-JNK pathway and suggest that differentially expressed GADD45 family members fine-tune stress-inducible JNK activity. © 2017 Elsevier Inc. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Embargo Period 12 months | |||||
権利 | ||||||
権利情報 | Copyright © 2017 Elsevier Inc.(CC-BY NC ND) | |||||
権利 | ||||||
権利情報 | http://www.elsevier.com/locate/issn/00039861 | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa |