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GADD45 family proteins suppress JNK signaling by targeting MKK7
https://doi.org/10.24517/00049540
https://doi.org/10.24517/0004954069516ddf-27bb-4735-9e85-e9c62da6d1ef
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ME-PR-SAKURAI-H-1.pdf (2.6 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||
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| 公開日 | 2017-12-22 | |||||||
| タイトル | ||||||||
| タイトル | GADD45 family proteins suppress JNK signaling by targeting MKK7 | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| ID登録 | ||||||||
| ID登録 | 10.24517/00049540 | |||||||
| ID登録タイプ | JaLC | |||||||
| 著者 |
Ueda, Takumi
× Ueda, Takumi× Kohama, Yuri× Kuge, Ayana× Kido, Eriko× Sakurai, Hiroshi |
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| 著者別表示 |
櫻井, 博
× 櫻井, 博
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| 提供者所属 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | 金沢大学医薬保健研究域保健学系 | |||||||
| 書誌情報 |
Archives of Biochemistry and Biophysics 巻 635, p. 1-7, 発行日 2017-12-01 |
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| ISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 0003-9861 | |||||||
| NCID | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AA00547159 | |||||||
| DOI | ||||||||
| 関連タイプ | isVersionOf | |||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | 10.1016/j.abb.2017.10.005 | |||||||
| 出版者 | ||||||||
| 出版者 | Academic Press Inc. | |||||||
| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Growth arrest and DNA damage-inducible 45 (GADD45) family genes encode related proteins, including GADD45α, GADD45β, and GADD45γ. In HeLa cells, expression of GADD45 members is differentially regulated under a variety of environmental conditions, but thermal and genotoxic stresses induce the expression of all genes. The heat shock response of GADD45β is mediated by the heat shock transcription factor 1 (HSF1), and GADD45β is necessary for heat stress survival. Heat and genotoxic stress-induced activation of c-Jun N-terminal kinase (JNK) is suppressed by the expression of GADD45 proteins. GADD45 proteins bind the JNK kinase mitogen-activated protein kinase kinase 7 (MKK7) and inhibit its activity, even under normal physiological conditions. Our findings indicate that GADD45 essentially suppresses the MKK7-JNK pathway and suggest that differentially expressed GADD45 family members fine-tune stress-inducible JNK activity. © 2017 Elsevier Inc. | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | Embargo Period 12 months | |||||||
| 権利 | ||||||||
| 権利情報 | Copyright © 2017 Elsevier Inc.(CC-BY NC ND) | |||||||
| 権利 | ||||||||
| 権利情報 | http://www.elsevier.com/locate/issn/00039861 | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | AM | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||
