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肝炎ウイルス複製を支持する新規肝癌由来培養細胞の樹立
https://doi.org/10.24517/00050629
https://doi.org/10.24517/0005062907559ff2-5865-42fe-bc9d-ecd1bd8d4ad8
名前 / ファイル | ライセンス | アクション |
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ME-PR-HONDA-M-kaken 2016-6p.pdf (116.7 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2018-04-26 | |||||
タイトル | ||||||
タイトル | 肝炎ウイルス複製を支持する新規肝癌由来培養細胞の樹立 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Establishment new HCC derived cell lines that support efficient hepatitis virus replication | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00050629 | |||||
ID登録タイプ | JaLC | |||||
著者別表示 |
Honda, Masao
× Honda, Masao |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医薬保健研究域保健学系 | |||||
書誌情報 |
平成27(2015)年度 科学研究費補助金 挑戦的萌芽研究 研究成果報告書 en : 2015 Fiscal Year Final Research Report 巻 2014-04-01 - 2016-03-31, p. 6p., 発行日 2016-05-19 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | ゲノタイプ1b型HCV 感染症例の肝細胞癌手術検体から癌幹細胞マーカーEpCAM陽性細胞分画を単離し、培養皿で継代が可能な細胞株(KH)を樹立した。KH細胞はJFH-1株やHJ3-5株のHCVの感染・複製を効率良く支持した。KH細胞はRIG-Iの変異を認めず、IFN誘導が保たれ、HCVの増殖は感染直後一端漸減し、再上昇を求めた。KH細胞はp53野生型であり、NOD-SCIDマウスに効率よく腫瘍を形成した。以上より、HCV感染・複製を支持する新規肝癌培養細胞株KH細胞を樹立した。KH細胞のゲノタイプ1bのHCV複製の確立には更なる検討が必要と考えられた。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We established a new cell line that is positive for cancer stem cell marker, EpCAM and supports efficient HCV replication and infection (JFH-1 and HJ3-5), from HCC tissue infected with genotype 1b HCV. KH cells have intact RIG-I sequence and produce IFN signaling, therefore, HCV replication once decline and increased again after infection. TP53 status of KH is wild and established tumor formation in NOD-SCID mice. Thus, we established a new HCC cell line that support efficient HCV replication and infection. Further studies should be needed to establish KH derived cells that support an efficient genotype 1b HCV replication. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:26670378, 研究期間(年度):2014-04-01 - 2016-03-31 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:研究課題「肝炎ウイルス複製を支持する新規肝癌由来培養細胞の樹立」課題番号26670378 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26670378/26670378seika/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=00272980 | |||||
関連名称 | https://kaken.nii.ac.jp/search/?qm=00272980 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26670378/ | |||||
関連名称 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26670378/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26670378/26670378seika/ | |||||
関連名称 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26670378/26670378seika/ |