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造血幹細胞におけるHLAアレル欠失現象を利用した再生不良性貧血自己抗原の同定
https://doi.org/10.24517/00051105
https://doi.org/10.24517/0005110582fb6d86-e2ba-4fe5-a274-9157a1291b69
名前 / ファイル | ライセンス | アクション |
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ME-PR-NAKAO-S-kaken 2013-4p.pdf (500.9 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2018-06-18 | |||||
タイトル | ||||||
タイトル | 造血幹細胞におけるHLAアレル欠失現象を利用した再生不良性貧血自己抗原の同定 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Identification of auto-antigens in acquired aplastic anemia associated with clonal hematopoiesis by hematopoietic stem cells with uniparental disomy of chromosome 6p. | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00051105 | |||||
ID登録タイプ | JaLC | |||||
著者別表示 |
Nakao, Shinji
× Nakao, Shinji |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医薬保健研究域医学系 | |||||
書誌情報 |
平成24(2012)年度 科学研究費補助金 挑戦的萌芽研究 研究成果報告書 en : 2012 Fiscal Year Final Research Report 巻 2011-2012, p. 4p., 発行日 2013-05-20 |
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出版者 | ||||||
出版者 | 金沢大学医薬保健研究域医学系 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 再生不良性貧血(AA)症例におけるHLA-Aアレル欠失血球陽性例の頻度を明らかにするため、抗HLA-Aアレル特異的抗体による検出感度を改良し、診断後間もない例を検索したところ、21症例中6例(28.6%)が陽性であり、欠失血球の全顆粒球中の割合は3.9% - 61.1%(中央値8.4%)と、既治療よりも低比率であった。一方、HLA-Aアレル欠失血球陽性AA患者の末梢血CD8陽性細胞を、HLA-B*40:02遺伝子導入K562 陽性細胞で刺激することにより、HLA-B*40:02導入K562のみを特異的に傷害する細胞傷害性T細胞(CTL)クローン(A6)を樹立した。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | To determine the exact prevalence of HLA-A allele-lacking leukocytes (HLA-LLs) in patients with acquired aplastic anemia (AA), we improved the sensitivity of flow cytometry and examined peripheral blood leukocytes of patients with newly-diagnosed AA patients. HLA-LLs were detectable in 6 (28.6%) of 21 patients who were heterozygous with the HLA-A allele. The percentage of HLA-A allele-lacking granulocytes in the total granulocytes ranged from 3.9% to 61.1% (median 8.4%), which was lower than that in patients in remission after immunosuppressive therapy. Cytotoxic T cell (CTL) clones (A6) were successfully established from one of the patients possessing HLA-LLs by stimulating patient’s CD8+T cells with K562 cells transfected with HLA-B*40:02 gene. A6 CTL killed K562 in B*40:02 restricted manner but did not kill other cells including EB virus-transformed lymphoblastoid cell line and Jurkat T cell line transduced with B*40:02. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:23659486, 研究期間(年度):2011-2012 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:研究課題「造血幹細胞におけるHLAアレル欠失現象を利用した再生不良性貧血自己抗原の同定」課題番号23659486 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23659486/23659486seika/)を加工して作成 |
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著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=70217660 | |||||
関連名称 | https://kaken.nii.ac.jp/search/?qm=70217660 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659486/ | |||||
関連名称 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659486/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23659486/23659486seika/ | |||||
関連名称 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23659486/23659486seika/ |