WEKO3
インデックスリンク
アイテム
{"_buckets": {"deposit": "473aa32a-4642-458a-96b0-45584429cf49"}, "_deposit": {"created_by": 18, "id": "45362", "owners": [18], "pid": {"revision_id": 0, "type": "depid", "value": "45362"}, "status": "published"}, "_oai": {"id": "oai:kanazawa-u.repo.nii.ac.jp:00045362", "sets": ["2816"]}, "author_link": ["580", "78873"], "item_9_biblio_info_8": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2018-06-07", "bibliographicIssueDateType": "Issued"}, "bibliographicPageStart": "5p.", "bibliographicVolumeNumber": "2016-04-01 - 2018-03-31", "bibliographic_titles": [{"bibliographic_title": "平成29(2017)年度 科学研究費補助金 若手研究(B) 研究成果報告書"}, {"bibliographic_title": "2017 Fiscal Year Final Research Report", "bibliographic_titleLang": "en"}]}]}, "item_9_creator_33": {"attribute_name": "著者別表示", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Masuo, Yusuke"}], "nameIdentifiers": [{"nameIdentifier": "78873", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "90708140", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=90708140"}]}]}, "item_9_description_21": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "肝消失型薬物の一部は、血漿中からの消失が慢性腎障害時に遅延する。そこで、OATP1B1阻害作用を有する生体内化合物を探索したところ、6-OH indoleはOATP1B1を阻害した。血漿中6-OH indole濃度は、腎障害患者において、正常腎機能患者よりも血漿中濃度が高かった。この化合物によるOATP1B1阻害作用は持続的であり、プレインキュベーション時のみに添加した際にも阻害作用を有した。さらに、本化合物は、ヒト初代培養肝細胞でestrone 3-sulfateの細胞内取り込みを阻害した。本化合物は、慢性腎障害時に血液中に蓄積してOATP1B1の機能阻害を引き起こすことが示唆された。", "subitem_description_type": "Abstract"}, {"subitem_description": "Several uremic tocxins have been proposed to inhibit hepatic uptake transporters. The purpose of this study is to find possible inhibition of OATP1B1 by newly identified uremic toxins, 6-OH indole. 6-OH indole inhibited OATP1B1-mediated uptake of [3H]estrone sulfate in HEK293/OATP1B1 cells. Plasma concentration of 6-OH indole was higher in patients with severe renal failure than that in patients without renal failure. The inhibition pattern of OATP1B1 by 6-OH indole was long-lasting, since its inhibition was maintained after 6-OH indole was washed out. Also, 6-OH indole inhibited uptake of estrone sulfate in primary cultured hepatocytes without changing mRNA expression of OATP1B1. These results suggest that increase of 6-OH indole in plasma during CKD could at least partially explain the delayed elimination of OATP1B1 substrate drugs.", "subitem_description_type": "Abstract"}]}, "item_9_description_22": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "研究課題/領域番号:16K18934, 研究期間(年度):2016-04-01 - 2018-03-31", "subitem_description_type": "Other"}, {"subitem_description": "出典:研究課題「慢性腎障害時の肝膜輸送体・薬物代謝酵素の系統的な活性変動の解析と予測法開発」課題番号16K18934\n(KAKEN:科学研究費助成事業データベース(国立情報学研究所)) \n(https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K18934/16K18934seika/)を加工して作成", "subitem_description_type": "Other"}]}, "item_9_description_5": {"attribute_name": "提供者所属", "attribute_value_mlt": [{"subitem_description": "金沢大学医薬保健研究域薬学系", "subitem_description_type": "Other"}]}, "item_9_identifier_registration": {"attribute_name": "ID登録", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.24517/00051699", "subitem_identifier_reg_type": "JaLC"}]}, "item_9_relation_28": {"attribute_name": "関連URI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "https://kaken.nii.ac.jp/search/?qm=90708140"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://kaken.nii.ac.jp/search/?qm=90708140", "subitem_relation_type_select": "URI"}}, {"subitem_relation_name": [{"subitem_relation_name_text": "https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K18934/"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K18934/", "subitem_relation_type_select": "URI"}}, {"subitem_relation_name": [{"subitem_relation_name_text": "https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K18934/16K18934seika/"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K18934/16K18934seika/", "subitem_relation_type_select": "URI"}}]}, "item_9_version_type_25": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "増尾, 友佑"}], "nameIdentifiers": [{"nameIdentifier": "580", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "90708140", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=90708140"}, {"nameIdentifier": "90708140", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=90708140"}, {"nameIdentifier": "90708140", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000090708140"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-04-19"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "PH-PR-MASUO-Y-kaken 2018-5p.pdf", "filesize": [{"value": "169.9 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 169900.0, "url": {"label": "PH-PR-MASUO-Y-kaken 2018-5p.pdf", "url": "https://kanazawa-u.repo.nii.ac.jp/record/45362/files/PH-PR-MASUO-Y-kaken 2018-5p.pdf"}, "version_id": "d7f523dc-a687-43c7-9d4f-057968b75f31"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "トランスポーター", "subitem_subject_scheme": "Other"}, {"subitem_subject": "慢性腎障害", "subitem_subject_scheme": "Other"}, {"subitem_subject": "尿毒素", "subitem_subject_scheme": "Other"}, {"subitem_subject": "メタボロミクス", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "research report", "resourceuri": "http://purl.org/coar/resource_type/c_18ws"}]}, "item_title": "慢性腎障害時の肝膜輸送体・薬物代謝酵素の系統的な活性変動の解析と予測法開発", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "慢性腎障害時の肝膜輸送体・薬物代謝酵素の系統的な活性変動の解析と予測法開発"}, {"subitem_title": "Developments in estimation of the functional changes of transporters and drug metabolizing enzymes during renal failure", "subitem_title_language": "en"}]}, "item_type_id": "9", "owner": "18", "path": ["2816"], "permalink_uri": "https://doi.org/10.24517/00051699", "pubdate": {"attribute_name": "公開日", "attribute_value": "2019-04-19"}, "publish_date": "2019-04-19", "publish_status": "0", "recid": "45362", "relation": {}, "relation_version_is_last": true, "title": ["慢性腎障害時の肝膜輸送体・薬物代謝酵素の系統的な活性変動の解析と予測法開発"], "weko_shared_id": -1}
慢性腎障害時の肝膜輸送体・薬物代謝酵素の系統的な活性変動の解析と予測法開発
https://doi.org/10.24517/00051699
https://doi.org/10.24517/0005169923b27167-a363-4949-ad0f-948cf4e0e9bd
名前 / ファイル | ライセンス | アクション |
---|---|---|
PH-PR-MASUO-Y-kaken 2018-5p.pdf (169.9 kB)
|
Item type | 報告書 / Research Paper(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2019-04-19 | |||||
タイトル | ||||||
タイトル | 慢性腎障害時の肝膜輸送体・薬物代謝酵素の系統的な活性変動の解析と予測法開発 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Developments in estimation of the functional changes of transporters and drug metabolizing enzymes during renal failure | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
ID登録 | ||||||
ID登録 | 10.24517/00051699 | |||||
ID登録タイプ | JaLC | |||||
著者別表示 |
Masuo, Yusuke
× Masuo, Yusuke |
|||||
提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学医薬保健研究域薬学系 | |||||
書誌情報 |
平成29(2017)年度 科学研究費補助金 若手研究(B) 研究成果報告書 en : 2017 Fiscal Year Final Research Report 巻 2016-04-01 - 2018-03-31, p. 5p., 発行日 2018-06-07 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 肝消失型薬物の一部は、血漿中からの消失が慢性腎障害時に遅延する。そこで、OATP1B1阻害作用を有する生体内化合物を探索したところ、6-OH indoleはOATP1B1を阻害した。血漿中6-OH indole濃度は、腎障害患者において、正常腎機能患者よりも血漿中濃度が高かった。この化合物によるOATP1B1阻害作用は持続的であり、プレインキュベーション時のみに添加した際にも阻害作用を有した。さらに、本化合物は、ヒト初代培養肝細胞でestrone 3-sulfateの細胞内取り込みを阻害した。本化合物は、慢性腎障害時に血液中に蓄積してOATP1B1の機能阻害を引き起こすことが示唆された。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Several uremic tocxins have been proposed to inhibit hepatic uptake transporters. The purpose of this study is to find possible inhibition of OATP1B1 by newly identified uremic toxins, 6-OH indole. 6-OH indole inhibited OATP1B1-mediated uptake of [3H]estrone sulfate in HEK293/OATP1B1 cells. Plasma concentration of 6-OH indole was higher in patients with severe renal failure than that in patients without renal failure. The inhibition pattern of OATP1B1 by 6-OH indole was long-lasting, since its inhibition was maintained after 6-OH indole was washed out. Also, 6-OH indole inhibited uptake of estrone sulfate in primary cultured hepatocytes without changing mRNA expression of OATP1B1. These results suggest that increase of 6-OH indole in plasma during CKD could at least partially explain the delayed elimination of OATP1B1 substrate drugs. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究課題/領域番号:16K18934, 研究期間(年度):2016-04-01 - 2018-03-31 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 出典:研究課題「慢性腎障害時の肝膜輸送体・薬物代謝酵素の系統的な活性変動の解析と予測法開発」課題番号16K18934 (KAKEN:科学研究費助成事業データベース(国立情報学研究所)) (https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K18934/16K18934seika/)を加工して作成 |
|||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/search/?qm=90708140 | |||||
関連名称 | https://kaken.nii.ac.jp/search/?qm=90708140 | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K18934/ | |||||
関連名称 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K18934/ | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K18934/16K18934seika/ | |||||
関連名称 | https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K18934/16K18934seika/ |