WEKO3
インデックスリンク
アイテム
Par6 regulates skeletogenesis and gut differentiation in sea urchin larvae
http://hdl.handle.net/2297/32461
http://hdl.handle.net/2297/324616662ebf8-519f-4040-bc43-f4e443ca4e48
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
SC-PR-YAMAGUCHI-M-269.pdf (994.8 kB)
|
|
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-10-03 | |||||
| タイトル | ||||||
| タイトル | Par6 regulates skeletogenesis and gut differentiation in sea urchin larvae | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Shiomi, Kosuke
× Shiomi, Kosuke× Yamazaki, Atsuko× Kagawa, Mitsuyoshi× Kiyomoto, Masato× Yamaguchi, Masaaki |
|||||
| 書誌情報 |
Development Genes and Evolution 巻 222, 号 5, p. 269-278, 発行日 2012-09-01 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0949-944X | |||||
| NCID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA11089872 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1007/s00427-012-0409-5 | |||||
| 出版者 | ||||||
| 出版者 | Springer-Verlag | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Partitioning-defective (par) genes were originally identified as genes that are essential for the asymmetric division of the Caenorhabditis elegans zygote. Studies have since revealed that the gene products are part of an evolutionarily conserved PAR-atypical protein kinase C system involved in cell polarity in various biological contexts. In this study, we analyzed the function of par6 during sea urchin morphogenesis by morpholino-mediated knockdown and by manipulation swapping of the primary mesenchyme cells (PMCs). Loss of Par6 resulted in defects in skeletogenesis and gut differentiation in larvae. Phenotypic analyses of chimeras constructed by PMC swapping showed that Par6 in non-PMCs is required for differentiation of archenteron into functional gut. In contrast, Par6 in both PMCs and ectodermal cells cooperatively regulates skeletogenesis. We suggest that Par6 in PMCs plays an immediate role in the deposition of biomineral in the syncytial cable, whereas Par6 in ectoderm may stabilize skeletal rods via an unknown signal(s). © 2012 Springer-Verlag. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
