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High-speed atomic force microscopy reveals rotary catalysis of rotor-less F1-ATPase
https://doi.org/10.24517/00010902
https://doi.org/10.24517/0001090299d1ad87-f4db-48d3-bfe7-e7f5a85bf8d5
名前 / ファイル | ライセンス | アクション |
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UchihashiScience2011.pdf (13.6 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-03 | |||||
タイトル | ||||||
タイトル | High-speed atomic force microscopy reveals rotary catalysis of rotor-less F1-ATPase | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
ID登録 | ||||||
ID登録 | 10.24517/00010902 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Uchihashi, Takayuki
× Uchihashi, Takayuki× Iino, Ryota× Ando, Toshio× Noji, Hiroyuki |
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著者別表示 |
内橋, 貴之
× 内橋, 貴之× 安藤, 敏夫 |
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提供者所属 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 金沢大学ナノ生命科学研究所 / 金沢大学理工研究域数物科学系 | |||||
書誌情報 |
Science 巻 333, 号 6043, p. 755-758, 発行日 2011-08-05 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0036-8075 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.00610.1126/science.1205510 | |||||
出版者 | ||||||
出版者 | Science AAAS | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | F1 is an adenosine triphosphate (ATP)–driven motor in which three torque-generating β subunits in the α3β3 stator ring sequentially undergo conformational changes upon ATP hydrolysis to rotate the central shaft γ unidirectionally. Although extensive experimental and theoretical work has been done, the structural basis of cooperative torque generation to realize the unidirectional rotation remains elusive. We used high-speed atomic force microscopy to show that the rotorless F1 still “rotates”; in the isolated α3β3 stator ring, the three β subunits cyclically propagate conformational states in the counterclockwise direction, similar to the rotary shaft rotation in F1. The structural basis of unidirectionality is programmed in the stator ring. These findings have implications for cooperative interplay between subunits in other hexameric ATPases. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関連URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.sciencemag.org/ |