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Expression of 20-hydroxyecdysone-induced genes in the silkworm brain and their functional analysis in post-embryonic development
http://hdl.handle.net/2297/12347
http://hdl.handle.net/2297/1234724fce13f-e303-4f7b-9265-1401e16e307a
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
SC-PR-IWAMI-M-1001.pdf (4.3 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-10-03 | |||||
| タイトル | ||||||
| タイトル | Expression of 20-hydroxyecdysone-induced genes in the silkworm brain and their functional analysis in post-embryonic development | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Monwar, Hossain
× Monwar, Hossain× Shimizu, Sakiko× Matsuki, Masahiko× Imamura, Masanori× Sakurai, Sho× Iwami, Masafumi |
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| 提供者所属 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 金沢大学理工研究域自然システム学系 | |||||
| 書誌情報 |
Insect Biochemistry and Molecular Biology 巻 38, 号 11, p. 1001-1007, 発行日 2008-11-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0965-1748 | |||||
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| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA10828030 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.ibmb.2008.08.006 | |||||
| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The insect brain is the center of developmental control, from which ecdysone governs brain morphogenesis and regulates gene expression cascades associated with molting and metamorphosis. In order to identify the 20-hydroxyecdysone (20E)-inducible genes responsible for molting and metamorphosis, we constructed a 20E-induced subtraction complementary DNA library from the fifth instar larval brain of the silkworm Bombyx mori. We isolated 10 genes, designated as bombeil-1 to bombeil-10, three of which did not show any sequence similarity to previously identified Bombyx genes. Whole-mount in situ hybridization revealed that all of these bombeil messenger RNAs were exclusively located in two pairs of lateral neurosecretory cells in the larval brain, known as prothoracicotropic hormone (PTTH)-producing cells. RNA-interference knockdown targeting bombeil-2 resulted in larval-pupal molt defects, and adult wing and leg malformations. These results, together with the cell-specific co-localization of bombeil transcripts with PTTH, suggest that bombeil genes play important roles during larval-pupal-adult development. © 2008 Elsevier Ltd. All rights reserved | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 関連URI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | http://dx.doi.org/10.1016/j.ibmb.2008.08.006 | |||||
| 関連URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.elsevier.com/locate/issn/09651748 | |||||
