WEKO3
インデックスリンク
アイテム
A cell-autonomous role for JSAP1 and JLP in mouse cerebellar Purkinje cell survival
https://doi.org/10.24517/00011108
https://doi.org/10.24517/0001110891fe5023-d4c6-44e4-b6c9-af561c3474c8
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AA00835991-59_51-60.pdf (4.0 MB)
|
.png)
|
| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-10-03 | |||||
| タイトル | ||||||
| タイトル | A cell-autonomous role for JSAP1 and JLP in mouse cerebellar Purkinje cell survival | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Axonal swelling | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Knockout mice | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Neuronal degeneration | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| ID登録 | ||||||
| ID登録 | 10.24517/00011108 | |||||
| ID登録タイプ | JaLC | |||||
| 著者 |
Ishikawa, Momoe
× Ishikawa, Momoe× Sato, Tokiharu× Kiyonari, Hiroshi× Yoshioka, Katsuji |
|||||
| 著者別表示 |
石川, 桃絵
× 石川, 桃絵× 佐藤, 時春× 善岡, 克次 |
|||||
| 書誌情報 |
The science reports of the Kanazawa University = 金沢大学理科報告 巻 59, p. 51-60, 発行日 2015-01-01 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0022-8338 | |||||
| NCID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00835991 | |||||
| 出版者 | ||||||
| 出版者 | Institute of Science and Engineering, Kanazawa University = 金沢大学 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We previously reported that the structurally related JNK scaffolding proteins JSAP1 and JLP play functionally redundant and key roles in maintaining mouse cere-bellar Purkinje cell (PC) survival, which may be related to their regulation of axonal transport. The JSAP1 and JLP proteins are also widely expressed in other cell types throughout the brain. Notably, in the cerebellum, JSAP1 is abundantly expressed in the pinceau, a cluster of basket cell (BC) axons and termini that surround the PC axon initial segment. Thus, it is possible that BC-expressed JSAP1 plays a role in PC survival. To investigate this possibility, we generated and analyzed mice containing a PC/BC-specific double knockout (DKO) of Jsap1 and Jlp (Jsap1:Jlp cDKO mice). These mice exhibited PC axonal dystrophy, followed by progressive PC loss, consistent with the phenotypes previously reported for PC-specific Jsap1 and Jlp DKO mice. Furthermore, we found that the phenotypes of Jsap1:Jlp cDKO PCs were rescued by PC-specific transgenic expression of JSAP1. Taken together, these results indicate that BC-expressed JSAP1 plays little or no role in PC survival, and that PC-expressed JSAP1 and JLP play cell-autonomous roles in preventing PC degeneration. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
