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The role of AGE-Rage system in the development of diabetic nephropathy in vivo
https://doi.org/10.24517/00012946
https://doi.org/10.24517/00012946b6612cc9-476c-487a-addd-51b9944aef90
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ME-PR-YAMAMOTO-Y-ICS.1245.45-50.pdf (22.5 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||
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| 公開日 | 2017-10-03 | |||||||||||||||||||
| タイトル | ||||||||||||||||||||
| タイトル | The role of AGE-Rage system in the development of diabetic nephropathy in vivo | |||||||||||||||||||
| 言語 | ||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||
| ID登録 | ||||||||||||||||||||
| ID登録 | 10.24517/00012946 | |||||||||||||||||||
| ID登録タイプ | JaLC | |||||||||||||||||||
| 著者 |
Yamamoto, Yasuhiko
× Yamamoto, Yasuhiko× Kato, Ichiro× Doi, Toshio× Yonekura, Hideto× Ohashi, Seiji× Takeuchi, Masayoshi× Watanabe, Takuo× Sakurai, Shigeru× Yasui, Kiyoshi× Ralica, Petrova G× Joynal, Abedin× Hui, Li× A.K.M.Azadur, Rahman× Takasawa, Shin× Okamoto, Hiroshi× Yamamoto, Hiroshi |
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| 著者別表示 |
山本, 靖彦
× 山本, 靖彦
× 米倉, 秀人
× 竹内, 正義
× 渡邉, 琢夫
× 櫻井, 繁
× 岡本, 宏
× 山本, 博
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| 提供者所属 | ||||||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||||||
| 内容記述 | 金沢大学大学院医学部医学系研究科 | |||||||||||||||||||
| 書誌情報 |
International Congress Series 巻 1245, p. 45-50, 発行日 2002-11-01 |
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| ISSN | ||||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||||
| 収録物識別子 | 0531-5131 | |||||||||||||||||||
| DOI | ||||||||||||||||||||
| 関連タイプ | isVersionOf | |||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||
| 関連識別子 | https://doi.org/10.1016/s0531-5131(02)00996-2 | |||||||||||||||||||
| 出版者 | ||||||||||||||||||||
| 出版者 | Elsevier | |||||||||||||||||||
| 抄録 | ||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||
| 内容記述 | Vascular complications are what eventually threaten the lives of diabetic patients. Here we show direct in vivo evidence that the interaction between advanced glycation end products (AGE), the formation of which is accelerated during prolonged hyperglycemic exposure, and a cell surface receptor for AGE (RAGE) is the major cause of such complications. We created transgenic mice that overexpress human RAGE in vascular cells and crossbred them with another transgenic line which develops insulin-dependent diabetes early after birth. The resultant double transgenic mice exhibited accelerated kidney changes compared with single transgenic littermates, and the nephropathy was ameliorated by an inhibitor of AGE formation. The AGE–RAGE system will thus be a promising target for overcoming diabetic complications. | |||||||||||||||||||
| 著者版フラグ | ||||||||||||||||||||
| 出版タイプ | AM | |||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||||
