| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-10-03 |
| タイトル |
|
|
タイトル |
Nurture vs. nature in diabetic vasculopathy: roles of advanced glycation endproducts and the receptor for them |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| ID登録 |
|
|
ID登録 |
10.24517/00012947 |
|
ID登録タイプ |
JaLC |
| 著者 |
Yamamoto, Yasuhiko
Yonekura, Hideto
Sakurai, Shigeru
Tanaka, Nobushige
Hui, Li
Khin-Mar, Myint
Chul-Hee, Kim
Harashima, Ai
Osawa, Mari
Takeuchi, Masayoshi
Watanabe, Takuo
Yamamoto, Hiroshi
|
| 著者別表示 |
山本, 靖彦
米倉, 秀人
原島, 愛
大澤, 真里
竹内, 正義
渡邉, 琢夫
山本, 博
|
| 提供者所属 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
金沢大学大学院医学部医学系研究科 |
| 書誌情報 |
International Congress Series
巻 1262,
p. 164-167,
発行日 2004-05-01
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0531-5131 |
| DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1016/j.ics.2003.12.035 |
| 出版者 |
|
|
出版者 |
Elsevier |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
As is diabetes itself, diabetic vasculopathy is a multifactor disease. Studies conducted in this lab revealed advanced glycation endproducts (AGE) as the major environmental account for vascular cell derangement characteristic of diabetes, and the receptor for AGE (RAGE) as the major genetic factor that responds to them. AGE fractions that caused the vascular derangement were proven to be RAGE ligands. When made diabetic, RAGE-overexpressing transgenic mice exhibited the exacerbation of the indices of nephropathy, and this was prevented by the inhibition of AGE formation. We also created RAGE-deficient mice. They showed marked amelioration of diabetic nephropathy. Extracellular signals and nuclear factors that induce the transcription of human RAGE gene were also identified, which would be regarded as risk factors of diabetic complications. Through an analysis of vascular polysomal poly(A)+ RNA, we came across a novel splice variant coding for a soluble RAGE protein, and named it endogenous secretory RAGE (esRAGE). esRAGE was able to capture AGE ligands and neutralize the AGE action on endothelial cells, suggesting that this variant has a potential to protect blood vessels from diabetes-induced injury. The AGE–RAGE system should thus be regarded as a candidate molecular target for overcoming this life- and quality of life (QOL)-threatening disease. |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
ME-PR-YAMAMOTO-Y-ICS.1262.164-167.pdf (18.0 kB)
.png)
