WEKO3
インデックスリンク
アイテム
β-Catenin up-regulates Nanog expression through interaction with Oct-3/4 in embryonic stem cells
http://hdl.handle.net/2297/3551
http://hdl.handle.net/2297/35511a11343a-dbfd-4279-8c50-9224cf1422d9
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ME-PR-YOKOTA-T-699.fdf (14.8 MB)
|
|
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-10-03 | |||||
| タイトル | ||||||
| タイトル | β-Catenin up-regulates Nanog expression through interaction with Oct-3/4 in embryonic stem cells | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Takao, Yukinari
× Takao, Yukinari× Yokota, Takashi× Koide, Hiroshi |
|||||
| 提供者所属 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 金沢大学大学院医学系研究科機能再生学 | |||||
| 書誌情報 |
Biochemical and Biophysical Research Communications 巻 353, 号 3, p. 699-705, 発行日 2007-02-16 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0006-291X | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1016/j.bbrc.2006.12.072 | |||||
| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | It is well known that mouse embryonic stem (ES) cells can be maintained by the presence of leukemia inhibitory factor (LIF). Recent studies have revealed that Wnt also exhibits activity similar to LIF. The molecular mechanism behind the maintenance of ES cells by these factors, however, is not fully understood. In this study, we found that LIF enhances level of nuclear β-catenin, a component of the Wnt signaling pathway. Expression of an activated mutant of β-catenin led to the long-term proliferation of ES cells, even in the absence of LIF. Furthermore, it was found that β-catenin up-regulates Nanog in an Oct-3/4-dependent manner and that β-catenin physically associates with Oct-3/4. These results suggest that up-regulating Nanog through interaction with Oct-3/4 involves β-catenin in the LIF- and Wnt-mediated maintenance of ES cell self-renewal. © 2006 Elsevier Inc. All rights reserved. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
