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Expression of fractalkine and its receptor, CX3CR1, in atopic dermatitis: Possible contribution to skin inflammation
http://hdl.handle.net/2297/1796
http://hdl.handle.net/2297/1796f26f747c-ff25-4844-8d31-71d90a06f538
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ME-PR-ECHIGO-T.pdf (485.9 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-10-03 | |||||
| タイトル | ||||||
| タイトル | Expression of fractalkine and its receptor, CX3CR1, in atopic dermatitis: Possible contribution to skin inflammation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Echigo, Takeshi
× Echigo, Takeshi× Hasegawa, Minoru× Shimada, Yuka× Takehara, Kazuhiko× Sato, Shinichi |
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| 書誌情報 |
Journal of Allergy and Clinical Immunology 巻 113, 号 5, p. 940-948, 発行日 2004-05-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0091-6749 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1016/j.jaci.2004.02.030 | |||||
| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: Fractalkine (FKN) induces activation and adhesion of leukocytes expressing its receptor, CX3CR1. FKN is released from the cell surface through proteolytic cleavage as soluble FKN (sFKN). Objective: We sought to assess FKN and CX3CR1 expression in the skin, serum sFKN levels, and CX3CR1 expression on blood leukocytes in patients with atopic dermatitis (AD). Methods: FKN and CX3CR1 expression in the skin was examined immunohistochemically. mRNA expression of FKN, thymus and activation-regulated chemokine, and macrophage-derived chemokine in the skin was assessed by means of real-time RT-PCR. Serum sFKN levels were assessed by using ELISA. Blood leukocytes were stained for CX3CR1 by means of flow cytometric analysis. Results: FKN was strongly expressed on endothelial cells in skin lesions of patients with AD and psoriasis but not in normal skin. FKN mRNA levels in AD lesional skin increased to a similar extent to thymus and activation-regulated chemokine and macrophage-derived chemokine mRNA levels. CX3CR1-expressing cells in the affected skin of patients with AD or psoriasis increased compared with those in normal skin. Serum sFKN levels were increased in patients with AD but not in patients with psoriasis relative to levels in healthy control subjects. Serum sFKN levels were associated with the disease severity and decreased with the improvement of skin lesions in patients with AD. CX3CR1+ cell frequencies and CX3CR1 expression levels were decreased in CD8+ T cells, monocytes, and natural killer cells from patients with AD, but this was not observed in patients with psoriasis. Conclusions: These results suggest that through functions in both membrane-bound and soluble forms, FKN plays an important role in the trafficking of CX3CR1+ leukocytes during the inflammation caused by AD. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 関連URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.elsevier.com/locate/issn/00916749 | |||||
