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Characterisation of bacterial orofacial infections using a new murine model
http://hdl.handle.net/2297/2455
http://hdl.handle.net/2297/245557564634-4545-496b-b02a-fe5604280775
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HE-PR-KARASAWA-T-092.pdf (140.4 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-10-03 | |||||
| タイトル | ||||||
| タイトル | Characterisation of bacterial orofacial infections using a new murine model | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Kuriyama, Tomoari
× Kuriyama, Tomoari× Karasawa, Tadahiro× Nakagawa, Kiyomasa× Kawashiri, Shuichi× Nakanishi, Isao× Nakamura, Shinichi× Yamamoto, Etsuhide |
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| 提供者所属 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 金沢大学大学院医学系研究科 | |||||
| 書誌情報 |
Microbial Pathogenesis 巻 29, 号 2, p. 115-120, 発行日 2000-08-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0882-4010 | |||||
| NCID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA10609161 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1006/mpat.2000.0375 | |||||
| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We devised a new murine orofacial infection model using bacteria from odontogenic infection origins and characterized the experimental infections. In this model, bacteria were injected into the submandible of mice. Streptococcus constellatus and Peptostreptococcus micros produced a single abscess at the injection site and their abscess-forming and lethal abilities were low: the median abscess-forming dose (AF50) of S. constellatus and P. micros were 108.5–10.7and 1010.2–10.6cfu/mouse, and their median lethal dose (LD50) were >11 and 1010.6–11cfu/mouse, respectively. Prevotella oralis and Fusobacterium nucleatum produced multiple abscesses and their abscess-forming and lethal abilities were strong: AF50of P. oralis andF. nucleatum were 106.0–6.4and 107.0–8.7cfu/mouse, and their LD50were 107.0–7.7and 108.3–9.9cfu/mouse, respectively. LD50of P. intermedia andP. gingivalis were 109.4–>11and 108.9–9.1cfu/mouse, respectively. Prevotella intermedia and Porphyromonas gingivalis generated a necrotizing lesion, which progressed rapidly. We conclude that this murine model could reflect human orofacial odontogenic infections and is useful to investigate the pathogenicity of causative bacteria of such infections. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
