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Effect of Prostaglandin E1 on Acute Ischemia-Reperfusion of Canine Small Intestine
http://hdl.handle.net/2297/39334
http://hdl.handle.net/2297/3933435c4adda-422e-4f52-8386-88de4ddd6683
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ME-PR-YAGI-M-39.pdf (625.3 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-10-03 | |||||
| タイトル | ||||||
| タイトル | Effect of Prostaglandin E1 on Acute Ischemia-Reperfusion of Canine Small Intestine | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Yagi, Masao
× Yagi, Masao× Tani, Takashi× Hashimoto, Tetsuo× Shimizu, Koichi× Miyazaki, Itsuo |
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| 書誌情報 |
Journal of Clinical Biochemistry and Nutrition 巻 21, 号 1, p. 39-44, 発行日 1996-01-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0912-0009 | |||||
| NCID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA10710201 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3164/jcbn.21.39 | |||||
| 出版者 | ||||||
| 出版者 | The Editorial Secretariat of JCBN = 日本酸化ストレス学会 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Ischemia-reperfusion of the small intestine associated with hemorrhage and other shock states is characterized by increased microvascular permeability and mucosal barrier dysfunction. Glycoproteins play an important role as a barrier to diffusion, and some of the functions of prostaglandin E1 (PGE1) are related to mucosal protein synthesis. The present experiment was conducted to clarify the effect of PGE1 on mucosal levels of glycoproteins and ATP following acute ischemia-reperfusion of the small intestine. The canine jejunum was isolated, and the blood flow was blocked for 30min with or without intravenous infusion of PGE1. Mucosal levels of ATP, Na+-K+ ATPase activity, glucosamine, galactosamine, and cAMP decreased, and plasma endotoxin levels in portal blood increased, after reperfusion in the PGE1-non-treated group. These changes were suppressed and mucosal levels of cAMP were increased by the administration of PGE1. These results suggest that mucosal permeability increased and mucin synthesis decreased markedly following acute ischemia-reperfusion and that the administration of PGE1 suppressed these changes by stimulation of ATP and cAMP synthesis. We also conclude that the administration of PGE1 is useful to protect against acute ischemia-reperfusion injury in the small intestine. | |||||
| 権利 | ||||||
| 権利情報 | Copyright © The Editorial Secretariat of JCBN 日本酸化ストレス学会 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 関連URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.jstage.jst.go.jp/browse/jcbn | |||||
| 関連URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://sfrrj.umin.jp/JCBN.htm | |||||
